| Gene Symbol |
TPX2
|
| Entrez Gene |
22974
|
| Alt Symbol |
C20orf1, C20orf2, DIL-2, DIL2, FLS353, GD:C20orf1, HCA519, HCTP4, REPP86, p100
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
TPX2, microtubule-associated
|
| Other Description |
TPX2, microtubule-associated protein homolog|TPX2, microtubule-associated, homolog|differentially expressed in cancerous and non-cancerous lung cells 2|differentially expressed in lung cells|hepatocellular carcinoma-associated antigen 519|hepatocellular carcinoma-associated antigen 90|preferentially expressed in colorectal cancer|protein fls353|restricted expression proliferation associated protein 100|restricted expression proliferation-associated protein 100|targeting protein for Xklp2
|
| Swissprots |
Q9H1R4 Q9ULW0 Q9UL00 Q9NRA3 Q9Y2M1 Q9UFN9 Q96RR5
|
| Accessions |
EAW76418 EAW76419 EAW76420 EAW76421 EAW76422 Q9ULW0 AB024704 BAA76931 AB027467 BAA85893 AF098158 AAF03248 AF146731 AAD33965 AF244547 AAF81695 AF287265 AAK83033 AK001391 BAG50902 AK093379 AK312549 BAG35446 AL117534 CAB55982 AY734680 AAU29203 BC004136 AAH04136 BC011357 AAH11357 BC020207 AAH20207 BM835456 BU181208 CB960160 JF432351 ADZ15568 XM_011528697 XP_011526999 XM_011528698 XP_011527000 XM_011528699 XP_011527001 XM_011528700 XP_011527002 NM_012112 NP_036244
|
| Function |
Spindle assembly factor. Required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules. Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation. {ECO:0000269|PubMed:18663142, ECO:0000269|PubMed:19208764}.
|
| Subcellular Location |
Nucleus. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=During mitosis it is strictly associated with the spindle pole and with the mitotic spindle, whereas during S and G2, it is diffusely distributed throughout the nucleus. Is released from the nucleus in apoptotic cells and is detected on apoptotic microtubules.
|
| Tissue Specificity |
Expressed in lung carcinoma cell lines but not in normal lung tissues.
|