TPX2

Gene Symbol TPX2
Entrez Gene 22974
Alt Symbol C20orf1, C20orf2, DIL-2, DIL2, FLS353, GD:C20orf1, HCA519, HCTP4, REPP86, p100
Species Human
Gene Type protein-coding
Description TPX2, microtubule-associated
Other Description TPX2, microtubule-associated protein homolog|TPX2, microtubule-associated, homolog|differentially expressed in cancerous and non-cancerous lung cells 2|differentially expressed in lung cells|hepatocellular carcinoma-associated antigen 519|hepatocellular carcinoma-associated antigen 90|preferentially expressed in colorectal cancer|protein fls353|restricted expression proliferation associated protein 100|restricted expression proliferation-associated protein 100|targeting protein for Xklp2
Swissprots Q9H1R4 Q9ULW0 Q9UL00 Q9NRA3 Q9Y2M1 Q9UFN9 Q96RR5
Accessions EAW76418 EAW76419 EAW76420 EAW76421 EAW76422 Q9ULW0 AB024704 BAA76931 AB027467 BAA85893 AF098158 AAF03248 AF146731 AAD33965 AF244547 AAF81695 AF287265 AAK83033 AK001391 BAG50902 AK093379 AK312549 BAG35446 AL117534 CAB55982 AY734680 AAU29203 BC004136 AAH04136 BC011357 AAH11357 BC020207 AAH20207 BM835456 BU181208 CB960160 JF432351 ADZ15568 XM_011528697 XP_011526999 XM_011528698 XP_011527000 XM_011528699 XP_011527001 XM_011528700 XP_011527002 NM_012112 NP_036244
Function Spindle assembly factor. Required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules. Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation. {ECO:0000269|PubMed:18663142, ECO:0000269|PubMed:19208764}.
Subcellular Location Nucleus. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=During mitosis it is strictly associated with the spindle pole and with the mitotic spindle, whereas during S and G2, it is diffusely distributed throughout the nucleus. Is released from the nucleus in apoptotic cells and is detected on apoptotic microtubules.
Tissue Specificity Expressed in lung carcinoma cell lines but not in normal lung tissues.

TPX2 CRISPR/Cas9 KO Plasmid (h) - sc-402581 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TPX2 HDR Plasmid (h) - sc-402581-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TPX2 Double Nickase Plasmid (h) - sc-402581-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TPX2 Double Nickase Plasmid (h2) - sc-402581-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TPX2 CRISPR Activation Plasmid (h) - sc-402581-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TPX2 CRISPR Activation Plasmid (h2) - sc-402581-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TPX2 Lentiviral Activation Particles (h) - sc-402581-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TPX2 Lentiviral Activation Particles (h2) - sc-402581-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TPX2 siRNA (h) - sc-37653 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TPX2 shRNA Plasmid (h) - sc-37653-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TPX2 shRNA (h) Lentiviral Particles - sc-37653-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TPX2 RNAi - H00022974-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU093011 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN21898 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21898 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR06118 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr06118

TPX2 siRNA (Human) - CRH7899 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

TPX2 - MBS8230665 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human TPX2(NM_012112.4) - SHL090768 from Creative biogene

Category siRNA
Species Reactivities Human

Human TPX2 siRNA - orb268401 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

TPX2 shRNA Plasmid (Human) - CHH7899 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

TPX2 miRNA 3'UTR clone - MiUTR1H-10690 from Creative biogene

Species Reactivities Human
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