| Gene Symbol |
SWAP70
|
| Entrez Gene |
23075
|
| Alt Symbol |
HSPC321, SWAP-70
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
SWAP switching B-cell complex 70kDa subunit
|
| Other Description |
switch-associated protein 70
|
| Swissprots |
Q7LCY6 Q9P061 Q9P0Z8 D3DQV1 O75135 Q9UH65
|
| Accessions |
EAW68582 EAW68583 EAW68584 EAW68585 Q9UH65 AB014540 BAA31615 AF134894 AAF61403 AF161439 AAF28999 AF210818 AAF24486 AI693686 AK027131 AK096859 BAG53381 AK304104 BAG65007 AL110154 BC000134 BC000616 AAH00616 DA413747 XM_005252830 XP_005252887 NM_001297714 NP_001284643 NM_015055 NP_055870
|
| Function |
Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm. Cell membrane. Nucleus. Cell projection, lamellipodium. Note=In resting B-cells it is localized mainly in the cytoplasm and upon cell activation it is recruited to the plasma membrane and then translocates to the nucleus. In activated, class-switching B-cells it is associated with membrane IgG but not IgM. Localized to loose actin filament arrays located behind actively extending lamellipodia.
|
| Tissue Specificity |
Expressed only in mature B-cells including those associated with mucosa-associated tissue and bronchus- associated tissue (PubMed:10681448). Widely expressed. Abundant in spleen, and fairly abundant in kidney, lung and liver. Also found in monocytes and macrophages (PubMed:12925760). {ECO:0000269|PubMed:10681448, ECO:0000269|PubMed:12925760}.
|