SWAP70
| Gene Symbol | SWAP70 |
|---|---|
| Entrez Gene | 23075 |
| Alt Symbol | HSPC321, SWAP-70 |
| Species | Human |
| Gene Type | protein-coding |
| Description | SWAP switching B-cell complex 70kDa subunit |
| Other Description | switch-associated protein 70 |
| Swissprots | Q7LCY6 Q9P061 Q9P0Z8 D3DQV1 O75135 Q9UH65 |
| Accessions | EAW68582 EAW68583 EAW68584 EAW68585 Q9UH65 AB014540 BAA31615 AF134894 AAF61403 AF161439 AAF28999 AF210818 AAF24486 AI693686 AK027131 AK096859 BAG53381 AK304104 BAG65007 AL110154 BC000134 BC000616 AAH00616 DA413747 XM_005252830 XP_005252887 NM_001297714 NP_001284643 NM_015055 NP_055870 |
| Function | Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion (By similarity). {ECO:0000250}. |
| Subcellular Location | Cytoplasm. Cell membrane. Nucleus. Cell projection, lamellipodium. Note=In resting B-cells it is localized mainly in the cytoplasm and upon cell activation it is recruited to the plasma membrane and then translocates to the nucleus. In activated, class-switching B-cells it is associated with membrane IgG but not IgM. Localized to loose actin filament arrays located behind actively extending lamellipodia. |
| Tissue Specificity | Expressed only in mature B-cells including those associated with mucosa-associated tissue and bronchus- associated tissue (PubMed:10681448). Widely expressed. Abundant in spleen, and fairly abundant in kidney, lung and liver. Also found in monocytes and macrophages (PubMed:12925760). {ECO:0000269|PubMed:10681448, ECO:0000269|PubMed:12925760}. |
SWAP-70 CRISPR/Cas9 KO Plasmid (h) - sc-403465 from Santa Cruz Biotechnology
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SWAP-70 HDR Plasmid (h) - sc-403465-HDR from Santa Cruz Biotechnology
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SWAP-70 Double Nickase Plasmid (h) - sc-403465-NIC from Santa Cruz Biotechnology
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SWAP-70 Double Nickase Plasmid (h2) - sc-403465-NIC-2 from Santa Cruz Biotechnology
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SWAP-70 CRISPR Activation Plasmid (h) - sc-403465-ACT from Santa Cruz Biotechnology
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SWAP-70 CRISPR Activation Plasmid (h2) - sc-403465-ACT-2 from Santa Cruz Biotechnology
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SWAP-70 Lentiviral Activation Particles (h) - sc-403465-LAC from Santa Cruz Biotechnology
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SWAP-70 Lentiviral Activation Particles (h2) - sc-403465-LAC-2 from Santa Cruz Biotechnology
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SWAP-70 siRNA (h) - sc-106898 from Santa Cruz Biotechnology
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SWAP-70 shRNA Plasmid (h) - sc-106898-SH from Santa Cruz Biotechnology
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SWAP-70 shRNA (h) Lentiviral Particles - sc-106898-V from Santa Cruz Biotechnology
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SWAP70 RNAi - H00023075-R01 from Novus Biologicals
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MISSION® esiRNA - EHU087181 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN20870 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20870 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR13833 from Sigma-Aldrich
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SWAP70 siRNA (Human) - CRH7979 from Cohesion Biosciences
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SWAP70 - MBS8212177 from MyBioSource
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shRNA set against Human SWAP70 (NM_015055.2) - SHH421416 from Creative biogene
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Human SWAP70 siRNA - orb268481 from Biorbyt
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SWAP70 shRNA Plasmid (Human) - CHH7979 from Cohesion Biosciences
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SWAP70 miRNA 3'UTR clone - MiUTR1H-10097 from Creative biogene
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