SWAP70

Gene Symbol	SWAP70
Entrez Gene	23075
Alt Symbol	HSPC321, SWAP-70
Species	Human
Gene Type	protein-coding
Description	SWAP switching B-cell complex 70kDa subunit
Other Description	switch-associated protein 70
Swissprots	Q7LCY6 Q9P061 Q9P0Z8 D3DQV1 O75135 Q9UH65
Accessions	EAW68582 EAW68583 EAW68584 EAW68585 Q9UH65 AB014540 BAA31615 AF134894 AAF61403 AF161439 AAF28999 AF210818 AAF24486 AI693686 AK027131 AK096859 BAG53381 AK304104 BAG65007 AL110154 BC000134 BC000616 AAH00616 DA413747 XM_005252830 XP_005252887 NM_001297714 NP_001284643 NM_015055 NP_055870
Function	Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion (By similarity). {ECO:0000250}.
Subcellular Location	Cytoplasm. Cell membrane. Nucleus. Cell projection, lamellipodium. Note=In resting B-cells it is localized mainly in the cytoplasm and upon cell activation it is recruited to the plasma membrane and then translocates to the nucleus. In activated, class-switching B-cells it is associated with membrane IgG but not IgM. Localized to loose actin filament arrays located behind actively extending lamellipodia.
Tissue Specificity	Expressed only in mature B-cells including those associated with mucosa-associated tissue and bronchus- associated tissue (PubMed:10681448). Widely expressed. Abundant in spleen, and fairly abundant in kidney, lung and liver. Also found in monocytes and macrophages (PubMed:12925760). {ECO:0000269|PubMed:10681448, ECO:0000269|PubMed:12925760}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SWAP70 full length protein - ab131864 from Abcam Category Protein Source Wheat germ Species Human

Human SWAP70 peptide - ab22913 from Abcam Category Peptide Species Human

Human SWAP70 protein fragment - ab161526 from Abcam Category Protein Source Wheat germ Species Human

SWAP70 Antibody Blocking Peptide - LS-E3266 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SWAP70 Antibody Blocking Peptide - LS-E25332 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SWAP70 Antibody Blocking Peptide - LS-E16855 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human SWAP70 Protein - H00023075-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human SWAP70 Protein - H00023075-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

SWAP70-Antibody-Center-Blocking-Peptide - BP1441c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SWAP70 blocking peptide - GTX89933-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Rat

SWAP70 Blocking Peptide - 33R-1326 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

SWAP70 Peptide - AC21-0160-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

SWAP70 - H00023075-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

SWAP70 - H00023075-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

SWAP70 - H00023075-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

SWAP70 - H00023075-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

SWAP70 Peptide - 46-453P from ProSci Category Peptide Species Human

Recombinant Human SWAP70, MYC/DDK-tagged - SWAP70-95H from Creative Biomart Category Protein Source HEK293 cells Species Human

Recombinant Human SWAP70, GST-tagged - SWAP70-96H from Creative Biomart Category Protein Source Wheat germ Species Human

Recombinant Human SWAP70, GST-tagged - SWAP70-97H from Creative Biomart Category Protein Source Wheat germ Species Human

Recombinant Human Switch-associated protein 70(SWAP70) - CSB-YP887026HU CSB-EP887026HU CSB-BP887026HU CSB-MP887026HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

SWAP70 - TP300074 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

SWAP70, Peptide - MBS426469 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat

SWAP70 Recombinant Protein Antigen - NBP1-82979PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

SWAP70-Antibody-C-term-Blocking-Peptide - BP1441b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

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