PAK1IP1

Gene Symbol	PAK1IP1
Entrez Gene	55003
Alt Symbol	MAK11, PIP1, WDR84, bA421M1.5, hPIP1
Species	Human
Gene Type	protein-coding
Description	PAK1 interacting protein 1
Other Description	PAK/PLC-interacting protein 1\|PAK1-interacting protein 1\|WD repeat-containing protein 84\|p21-activated protein kinase-interacting protein 1
Swissprots	Q96QJ8 Q96T87 Q5T4J2 Q9NWT1
Accessions	EAW55267 EAW55268 EAW55269 EAW55270 Q9NWT1 AF283303 AAK57477 AK000631 BAA91296 AK225516 BC010907 AAH10907 BU618231 DQ892798 ABM83724 DQ896045 ABM87044 XM_005249204 XP_005249261 XM_006715129 XP_006715192 XM_011514720 XP_011513022 XM_011514721 XP_011513023 NM_017906 NP_060376
Function	Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which have been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. {ECO:0000269\|PubMed:11371639}.
Subcellular Location	Nucleus, nucleolus {ECO:0000269\|PubMed:12429849}.
Tissue Specificity	Expressed in brain, colon, heart, kidney, liver, lung, muscle, peripheral blood leukocytes, placenta, small intestine, spleen and thymus. {ECO:0000269\|PubMed:11371639}.

PIP1 (A-15) - sc-101866 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	100 µg/ml
Host	Rabbit
Clonality	Polyclonal

PIP1 (A-15): sc-101866. Western blot analysis of PIP1 expression in K-562 (A), SK-N-MC (B) and Hep G2 (C) nuclear extracts.

Anti-PAK1 interacting protein 1 antibody - ab67348 from Abcam

Prices	$370.00
Sizes	50 µl
Host	Mouse
Clonality	Polyclonal

All lanes : Anti-PAK1 interacting protein 1 antibody (ab67348) at 1/500 dilutionLane 1 : PAK1 interacting protein 1 transfected 293T cell lysateLane 2 : Non transfected 293T cell lysateLysates/proteins at 25 µg per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

Anti-PAK1 interacting protein 1 antibody - ab176813 from Abcam

Prices	$370.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Detection of PAK1 interacting protein 1 by Western Blot of Immunprecipitate.ab176813 at 1µg/ml labeling PAK1 interacting protein 1 in HeLa whole cell lysate immunoprecipitated using ab176813 at 3µg/mg lysate (1 mg/IP; 20% of IP loaded/lane). Detection: Chemiluminescence with exposure time of 30 seconds.

Anti-PAK1 interacting protein 1 antibody - ab94340 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-PAK1IP1 / HPIP1 Antibody - LS-C40682 from LifeSpan Bioscience

Prices	$275.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-PAK1IP1 / HPIP1 Antibody - LS-C74967 from LifeSpan Bioscience

Prices	$325.00
Sizes	50 µl
Host	Rabbit
Clonality	Polyclonal

Anti-PAK1IP1 / HPIP1 Antibody (aa342-392) - LS-C288342 from LifeSpan Bioscience

Prices	$375.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-PAK1IP1 / HPIP1 Antibody - LS-C335510 from LifeSpan Bioscience

Prices	$305.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Western blot analysis of extracts of K-562 cell line, using PAK1IP1 antibody.

Anti-PAK1IP1 / HPIP1 Antibody (aa290-340) - LS-C288341 from LifeSpan Bioscience

Prices	$375.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Detection of Human PIP1/WDR84 by Western Blot. Samples: Whole cell lysate (50 ug) from HeLa, 293T, and Jurkat cells. Antibodies: Affinity purified rabbit anti-PIP1/WDR84 antibody used for WB at 0.4 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.

PAK1 interacting protein 1 Antibody - NBP1-90029 from Novus Biologicals

Prices	$419.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

PAK1 interacting protein 1 Antibody - H00055003-B02P from Novus Biologicals

Prices	$359.00
Sizes	50 µg
Host	Mouse
Clonality	Polyclonal

Western Blot: PAK1 interacting protein 1 Antibody [H00055003-B02P] - Analysis of PAK1IP1 expression in transfected 293T cell line by PAK1IP1 polyclonal antibody. Lane 1: PAK1IP1 transfected lysate(43.12 KDa). Lane 2: Non-transfected lysate.

PAK1 interacting protein 1 Antibody - H00055003-B02 from Novus Biologicals

Prices	$349.00
Sizes	50 µl
Host	Mouse
Clonality	Polyclonal

Western Blot: PAK1 interacting protein 1 Antibody [H00055003-B02] - analysis of PAK1IP1 expression in transfected 293T cell line by PAK1IP1 MaxPab polyclonal antibody (B02). Lane 1: PAK1IP1 transfected lysate (44.00 KDa). Lane 2: Non-transfected lysate.

PAK1 interacting protein 1 Antibody - NB100-77293 from Novus Biologicals

Prices	$359.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

PAK1 interacting protein 1 Antibody - H00055003-B01P from Novus Biologicals

Prices	$359.00
Sizes	50 µg
Host	Mouse
Clonality	Polyclonal

Western Blot: PAK1 interacting protein 1 Antibody [H00055003-B01P] - Analysis of PAK1IP1 expression in transfected 293T cell line by PAK1IP1 polyclonal antibody. Lane 1: PAK1IP1 transfected lysate(43.23 KDa). Lane 2: Non-transfected lysate.

PAK1 interacting protein 1 Antibody - H00055003-B01 from Novus Biologicals

Prices	$349.00
Sizes	50 µl
Host	Mouse
Clonality	Polyclonal

Western Blot: PAK1 interacting protein 1 Antibody [H00055003-B01] - analysis of PAK1IP1 expression in transfected 293T cell line by PAK1IP1 MaxPab polyclonal antibody (B01). Lane 1: PAK1IP1 transfected lysate (43.23 KDa). Lane 2: Non-transfected lysate.

PAK1 interacting protein 1 Antibody - NB100-77292 from Novus Biologicals

Prices	$249.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Western Blot: PAK1 interacting protein 1 Antibody [NB100-77292] - Detection of Human PIP1/WDR84 on HeLa whole cell lysate using NB100-77292. PIP1/WDR84 was also immunoprecipitated by rabbit anti-PIP1/WDR84 antibody NB100-77293.

PAK1 interacting protein 1 Antibody - NBP2-19681 from Novus Biologicals

Prices	$329.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-PAK1IP1 antibody produced in rabbit - HPA030112 from Sigma-Aldrich

Prices	$429.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

<B>Immunohistochemistry</B><BR/>Anti-PAK1IP1: <B>Cat. No. HPA030112</B>: Immunohistochemical staining of human colon shows strong cytoplasmic and nuclear positivity in glandular cells.

Anti-PAK1IP1 (331-344) antibody produced in rabbit - K2390 from Sigma-Aldrich

Prices	$342.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

<B>Immunofluorescence</B><BR/>Anti-PAK1IP1 (331-344) (RB): <B>Cat. No. K2390</B>: Immunofluorescence of HUVEC cells using PAK1IP1 (331-344) (RB), <B>Cat. No. K2390</B> (red) at a 1:100 dilution, taken at 40× magnification and nuclear staining with Hoescht 33342 (blue). Yale HTCB IF procedure used.<BR/>Images have been adjusted to improve viewing quality. If you would like the original image, please send a request to protocols@sial.com

Anti-PAK1IP1 antibody produced in mouse - SAB1407604 from Sigma-Aldrich

Prices	$347.00
Sizes	50 µg
Host	Mouse
Clonality	Polyclonal

<B>Immunofluorescence</B><BR/>Anti-PAK1IP1: <B>Cat. No. SAB1407604</B>: Antibody concentration: 10 μg/mL using HeLa cell.

Anti-PAK1IP1 antibody produced in mouse - SAB1409474 from Sigma-Aldrich

Prices	$347.00
Sizes	50 µg
Host	Mouse
Clonality	Polyclonal

<B>Immunofluorescence</B><BR/>Anti-PAK1IP1: <B>Cat. No. SAB1409474</B>: Antibody concentration: 10 μg/mL using HeLa cell.

PAK1IP1 antibody - 70R-19096 from Fitzgerald

Prices	$375.00
Sizes	50 µl
Host	Rabbit
Clonality	Polyclonal

PAK1IP1 Polyclonal Antibody - A4809 from ABclonal

Prices	$200.00, $480.00
Sizes	50 µg, 200 µg
Host	Rabbit
Clonality	Polyclonal

PAK1IP1 Antibody - abx003642 from Abbexa

Host	Rabbit
Clonality	Polyclonal

WDR84 / PIP1 antibody - 16071-1-AP from Acris Antibodies

Prices	$270.00
Sizes	150 µl
Host	Rabbit
Clonality	Polyclonal

K-562 cells were subjected to SDS PAGE followed by western blot with 16071-1-AP(PAK1IP1 antibody) at dilution of 1:400

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