| Gene Symbol |
PAK1IP1
|
| Entrez Gene |
55003
|
| Alt Symbol |
MAK11, PIP1, WDR84, bA421M1.5, hPIP1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
PAK1 interacting protein 1
|
| Other Description |
PAK/PLC-interacting protein 1|PAK1-interacting protein 1|WD repeat-containing protein 84|p21-activated protein kinase-interacting protein 1
|
| Swissprots |
Q96QJ8 Q96T87 Q5T4J2 Q9NWT1
|
| Accessions |
EAW55267 EAW55268 EAW55269 EAW55270 Q9NWT1 AF283303 AAK57477 AK000631 BAA91296 AK225516 BC010907 AAH10907 BU618231 DQ892798 ABM83724 DQ896045 ABM87044 XM_005249204 XP_005249261 XM_006715129 XP_006715192 XM_011514720 XP_011513022 XM_011514721 XP_011513023 NM_017906 NP_060376
|
| Function |
Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which have been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. {ECO:0000269|PubMed:11371639}.
|
| Subcellular Location |
Nucleus, nucleolus {ECO:0000269|PubMed:12429849}.
|
| Tissue Specificity |
Expressed in brain, colon, heart, kidney, liver, lung, muscle, peripheral blood leukocytes, placenta, small intestine, spleen and thymus. {ECO:0000269|PubMed:11371639}.
|