Gene Symbol | WDYHV1 |
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Entrez Gene | 55093 |
Alt Symbol | C8orf32 |
Species | Human |
Gene Type | protein-coding |
Description | WDYHV motif containing 1 |
Other Description | N-terminal Gln amidase|WDYHV motif-containing protein 1|nt(Q)-amidase|protein N-terminal glutamine amidohydrolase|protein NH2-terminal glutamine deamidase |
Swissprots | B4DE68 Q96HA8 Q9NW95 |
Accessions | EAW92037 EAW92038 EAW92039 Q96HA8 AK001066 BAA91488 AK225643 AK293492 BAG56979 AU119047 BC008781 AAH08781 BG528966 HQ448315 ADQ32795 XM_006716597 XP_006716660 XM_011517146 XP_011515448 XM_011517147 XP_011515449 XM_011517148 XP_011515450 XM_011517149 XP_011515451 XM_011517150 XP_011515452 XM_011517151 XP_011515453 XR_928337 XR_928338 NM_001283024 NP_001269953 NM_001283027 NP_001269956 NM_018024 NP_060494 |
Function | Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N- terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C- terminal glutamine and does not act on non-glutamine residues in any position. Does not deaminate acetylated N-terminal glutamine. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm, cytosol {ECO:0000250}. Nucleus {ECO:0000250}. |
Anti-wdyhv1 antibody - ab79869 from Abcam
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Anti-wdyhv1 antibody - N-terminal - ab182530 from Abcam
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Anti-WDYHV1 Antibody (aa30-79) - LS-C201950 from LifeSpan Bioscience
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Anti-WDYHV1 Antibody (aa106-136) - LS-C97296 from LifeSpan Bioscience
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wdyhv1 Antibody - NBP1-86722 from Novus Biologicals
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Anti-WDYHV1 antibody produced in rabbit - HPA024823 from Sigma-Aldrich
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Anti-WDYHV1 (116-130) antibody produced in rabbit - SAB1102347 from Sigma-Aldrich
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WDYHV1 Antibody - N-terminal region (ARP72013_P050) - ARP72013_P050 from Aviva Systems Biology
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WDYHV1 Antibody - middle region (OAAB01519) - OAAB01519 from Aviva Systems Biology
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WDYHV1-Antibody-Center - AP2809c from Abgent, a WuXi AppTec company
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WDYHV1 antibody - orb155418 from Biorbyt
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WDYHV1 Antibody - abx036296 from Abbexa
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WDYHV1 (Center) antibody - AP12459PU-N from Acris Antibodies
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WDYHV1 antibody - H00055093-B01P from Acris Antibodies
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WDYHV1, Polyclonal Antibody - MBS8504342 from MyBioSource
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WDYHV1 Antibody - E307071 from Enogene
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Rabbit Anti-Human WDYHV1 Polyclonal Antibody - DPABH-14084 from Creative Diagnostics
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WDYHV1 Polyclonal Antibody - PA5-12414 from Thermo Fisher Scientific
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WDYHV1, Polyclonal Antibody - MBS9205634 from MyBioSource
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Anti-WDYHV1 (center) antibody produced in rabbit - SAB1300703 from Sigma-Aldrich
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WDYHV1 Antibody,FITC conjugated - CSB-PA850306LC01HU from Cusabio
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WDYHV1 Antibody - CSB-PA850306LA01HU from Cusabio
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WDYHV1 Antibody,HRP conjugated - CSB-PA850306LB01HU from Cusabio
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WDYHV1 Antibody,Biotin conjugated - CSB-PA850306LD01HU from Cusabio
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Anti-WDYHV1 Antibody (N-Terminus) - LS-C378872 from LifeSpan Bioscience
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