Gene Symbol | WDYHV1 |
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Entrez Gene | 55093 |
Alt Symbol | C8orf32 |
Species | Human |
Gene Type | protein-coding |
Description | WDYHV motif containing 1 |
Other Description | N-terminal Gln amidase|WDYHV motif-containing protein 1|nt(Q)-amidase|protein N-terminal glutamine amidohydrolase|protein NH2-terminal glutamine deamidase |
Swissprots | B4DE68 Q96HA8 Q9NW95 |
Accessions | EAW92037 EAW92038 EAW92039 Q96HA8 AK001066 BAA91488 AK225643 AK293492 BAG56979 AU119047 BC008781 AAH08781 BG528966 HQ448315 ADQ32795 XM_006716597 XP_006716660 XM_011517146 XP_011515448 XM_011517147 XP_011515449 XM_011517148 XP_011515450 XM_011517149 XP_011515451 XM_011517150 XP_011515452 XM_011517151 XP_011515453 XR_928337 XR_928338 NM_001283024 NP_001269953 NM_001283027 NP_001269956 NM_018024 NP_060494 |
Function | Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N- terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C- terminal glutamine and does not act on non-glutamine residues in any position. Does not deaminate acetylated N-terminal glutamine. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm, cytosol {ECO:0000250}. Nucleus {ECO:0000250}. |
WDYHV1 Antibody Blocking Peptide - LS-E7117 from LifeSpan Bioscience
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WDYHV1-Antibody-Center-Blocking-Peptide - BP2809c from Abgent, a WuXi AppTec company
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WDYHV1 fusion protein - ag15147 from Proteintech Group
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WDYHV1 fusion protein - Ag14713 from Proteintech Group
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Recombinant Human WDYHV1, GST-tagged - WDYHV1-3725H from Creative Biomart
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Recombinant Human Protein N-terminal glutamine amidohydrolase(WDYHV1) - CSB-YP850306HU CSB-EP850306HU CSB-BP850306HU CSB-MP850306HU from Cusabio
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WDYHV1 - TP301055 from Acris Antibodies
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Human Protein N-Terminal Glutamine Amidohydrolase protein (N-GST) - orb311965 from Biorbyt
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wdyhv1 Recombinant Protein Antigen - NBP1-86722PEP from Novus Biologicals
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WDYHV1 Peptide, Human - M34GP17473H from Creative Peptides
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Human Glutamine Amidohydrolase protein - orb334317 from Biorbyt
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NTAQ1 Recombinant Protein - 92-506 from ProSci
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wdyhv1 Recombinant Protein Antigen - NBP2-58578PEP from Novus Biologicals
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Protein N-terminal glutamine amidohydrolase (WDYHV1), Recombinant Protein - MBS1476731 from MyBioSource
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Recombinant Human Protein N-terminal Glutamine Amidohydrolase,NTAQ1 - AP76141 from Signalway Antibody
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Human WDYHV1 protein - orb392716 from Biorbyt
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Recombinant Human WDYHV1 protein, His-tagged - WDYHV1-115H from Creative Biomart
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