| Gene Symbol |
WDYHV1
|
| Entrez Gene |
55093
|
| Alt Symbol |
C8orf32
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
WDYHV motif containing 1
|
| Other Description |
N-terminal Gln amidase|WDYHV motif-containing protein 1|nt(Q)-amidase|protein N-terminal glutamine amidohydrolase|protein NH2-terminal glutamine deamidase
|
| Swissprots |
B4DE68 Q96HA8 Q9NW95
|
| Accessions |
EAW92037 EAW92038 EAW92039 Q96HA8 AK001066 BAA91488 AK225643 AK293492 BAG56979 AU119047 BC008781 AAH08781 BG528966 HQ448315 ADQ32795 XM_006716597 XP_006716660 XM_011517146 XP_011515448 XM_011517147 XP_011515449 XM_011517148 XP_011515450 XM_011517149 XP_011515451 XM_011517150 XP_011515452 XM_011517151 XP_011515453 XR_928337 XR_928338 NM_001283024 NP_001269953 NM_001283027 NP_001269956 NM_018024 NP_060494
|
| Function |
Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N- terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C- terminal glutamine and does not act on non-glutamine residues in any position. Does not deaminate acetylated N-terminal glutamine. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm, cytosol {ECO:0000250}. Nucleus {ECO:0000250}.
|