WFDC2

Gene Symbol WFDC2
Entrez Gene 10406
Alt Symbol EDDM4, HE4, WAP5, dJ461P17.6
Species Human
Gene Type protein-coding
Description WAP four-disulfide core domain 2
Other Description WAP domain containing protein HE4-V4|WAP four-disulfide core domain protein 2|epididymal protein 4|epididymal secretory protein E4|epididymis-specific, whey-acidic protein type, four-disulfide core|major epididymis-specific protein E4|putative protease inhibitor WAP5
Swissprots Q96KJ1 Q8WXW2 Q6IB27 Q8WXV9 A2A2A5 A2A2A6 Q8WXW0 A6PVD5 Q14508 Q8WXW1
Accessions CAV31701 CAV31702 CAY39341 EAW75836 EAW75837 EAW75838 EAW75839 EAW75840 Q14508 AF330259 AAL37485 AF330260 AAL37486 AF330261 AAL37487 AF330262 AAL37488 AK225528 AK290288 BAF82977 AK311966 AY212888 AAO52683 BC039816 BC046106 AAH46106 BI759775 CR456977 CAG33258 EU831749 ACE87267 EU831825 ACE86584 HQ448483 ADQ32963 X63187 CAA44869 XM_011528495 XP_011526797 NM_006103 NP_006094 NM_080733 NM_080734 NM_080735 NM_080736
Function Broad range protease inhibitor. {ECO:0000269|PubMed:23139753}.
Subcellular Location Secreted {ECO:0000269|PubMed:15781627, ECO:0000269|PubMed:23139753}.
Tissue Specificity Expressed in a number of normal tissues, including male reproductive system, regions of the respiratory tract and nasopharynx. Highly expressed in a number of tumors cells lines, such ovarian, colon, breast, lung and renal cells lines. Initially described as being exclusively transcribed in the epididymis. {ECO:0000269|PubMed:15781627}.

HE4 (C-12) - sc-27570 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
HE4 (C-12): sc-27570. Western blot analysis of HE4 expression in PC-3 (A), DU 145 (B) and HeLa (C) whole cell lysates.

Anti-HE4 antibody - ab24480 from Abcam

Prices $382.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab24480 (4µg/ml) staining HE4 in human lung using an automated system (DAKO Autostainer Plus).Sections were rehydrated and antigen retrieved with the Dako 3 in 1 AR buffers EDTA pH 9.0 in a DAKO PT link. Slides were peroxidase blocked in 3% H2O2 in methanol for 10 mins. They were then blocked with Dako Protein block for 10 minutes (containing casein 0.25% in PBS) then incubated with primary antibody for 20 min and detected with Dako envision flex amplification kit for 30 minutes. Colorimetric detection was completed with Diaminobenzidine for 5 minutes. Slides were counterstained with Haematoxylin and coverslipped under DePeX. Please note that, for manual staining, optimization of primary antibody concentration and incubation time is recommended. Signal amplification may be required.

Anti-HE4 antibody - ab85179 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-HE4 antibody (ab85179) at 1 µg/mlLane 1 : Lung (Human) Tissue LysateLane 2 : Ovary (Human) Tissue Lysate - adult normal tissue (ab30222)Lysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-HE4 antibody - ab56699 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab56699 HE4 antibody at 1ug/ml.

Anti-HE4 antibody - ab130128 from Abcam

Prices $370.00
Sizes 200 µl
Host Goat
Clonality Polyclonal

Anti-HE4 antibody [EPR16658] - ab200828 from Abcam

Prices $347.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR16658
All lanes : Anti-HE4 antibody [EPR16658] (ab200828) at 1/1000 dilutionLane 1 : Human ovary cancer whole cell lysateLane 2 : NIH:OVCAR-3 (Human ovary adenocarcinoma) whole cell lysateLysates/proteins at 10 µg per lane.SecondaryAnti-Rabbit IgG (HRP), specific to the non-reduced form of IgG at 1/1000 dilution

Anti-HE4 antibody [EPR4743] - ab109298 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4743
All lanes : Anti-HE4 antibody [EPR4743] (ab109298) at 1/1000 dilutionLane 1 : HT29 cell lysateLane 2 : SW480 cell lysateLane 3 : Ovary cancer tissue lysateLane 4 : SK-OV-3 cell lysateLysates/proteins at 10 µg per lane.

Anti-HE4 antibody [EPR4743] (HRP) - ab198576 from Abcam

Prices $425.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4743
All lanes : Anti-HE4 antibody [EPR4743] (HRP) (ab198576) at 1/5000 dilutionLane 1 : HT29 (Human colon adenocarcinoma grade II cell line) Whole Cell LysateLane 2 : SW480 (Human colon adenocarcinoma cell line) Whole Cell LysateLane 3 : Ovary (Human) Whole Cell Lysate - tumor tissue (ab30220)Lysates/proteins at 10 µg per lane.developed using the ECL techniquePerformed under reducing conditions.

Anti-WFDC2 / HE4 Antibody (aa31-124, clone 2A7) - LS-C336333 from LifeSpan Bioscience

Prices $350.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2A7
IHC of paraffin-embedded Human thyroid tissue using anti-WFDC2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).

Anti-WFDC2 / HE4 Antibody (aa31-124, clone 1E12) - LS-C336312 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1E12
IHC of paraffin-embedded Carcinoma of Human prostate tissue using anti-WFDC2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).

Anti-WFDC2 / HE4 Antibody - LS-C132958 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µg
Host Sheep
Clonality Polyclonal

Anti-WFDC2 / HE4 Antibody (aa29-43) - LS-C112980 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-WFDC2 / HE4 Antibody (aa73-86) - LS-C154785 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-WFDC2 / HE4 Antibody (FITC) - LS-C211874 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-WFDC2 / HE4 Antibody - LS-C211882 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-WFDC2 / HE4 Antibody (HRP) - LS-C211885 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-WFDC2 / HE4 Antibody (aa31-124, Biotin) - LS-C211890 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-WFDC2 / HE4 Antibody - LS-C212298 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)

Anti-WFDC2 / HE4 Antibody (aa29-44) - LS-C305857 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-WFDC2 / HE4 Antibody (Biotin) - LS-C343009 from LifeSpan Bioscience

Prices $305.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-WFDC2 / HE4 Antibody (clone 1A23) - LS-C139169 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1A23
Detection limit for recombinant GST tagged WFDC2 is 0.3 ng/ml as a capture antibody.

Anti-WFDC2 / HE4 Antibody - LS-C343011 from LifeSpan Bioscience

Prices $275.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-WFDC2 / HE4 Antibody (Biotin) - LS-C343012 from LifeSpan Bioscience

Prices $305.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-WFDC2 / HE4 Antibody - LS-C343013 from LifeSpan Bioscience

Prices $275.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-WFDC2 / HE4 Antibody (Biotin) - LS-C343014 from LifeSpan Bioscience

Prices $305.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
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