| Gene Symbol |
WFDC2
|
| Entrez Gene |
10406
|
| Alt Symbol |
EDDM4, HE4, WAP5, dJ461P17.6
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
WAP four-disulfide core domain 2
|
| Other Description |
WAP domain containing protein HE4-V4|WAP four-disulfide core domain protein 2|epididymal protein 4|epididymal secretory protein E4|epididymis-specific, whey-acidic protein type, four-disulfide core|major epididymis-specific protein E4|putative protease inhibitor WAP5
|
| Swissprots |
Q96KJ1 Q8WXW2 Q6IB27 Q8WXV9 A2A2A5 A2A2A6 Q8WXW0 A6PVD5 Q14508 Q8WXW1
|
| Accessions |
CAV31701 CAV31702 CAY39341 EAW75836 EAW75837 EAW75838 EAW75839 EAW75840 Q14508 AF330259 AAL37485 AF330260 AAL37486 AF330261 AAL37487 AF330262 AAL37488 AK225528 AK290288 BAF82977 AK311966 AY212888 AAO52683 BC039816 BC046106 AAH46106 BI759775 CR456977 CAG33258 EU831749 ACE87267 EU831825 ACE86584 HQ448483 ADQ32963 X63187 CAA44869 XM_011528495 XP_011526797 NM_006103 NP_006094 NM_080733 NM_080734 NM_080735 NM_080736
|
| Function |
Broad range protease inhibitor. {ECO:0000269|PubMed:23139753}.
|
| Subcellular Location |
Secreted {ECO:0000269|PubMed:15781627, ECO:0000269|PubMed:23139753}.
|
| Tissue Specificity |
Expressed in a number of normal tissues, including male reproductive system, regions of the respiratory tract and nasopharynx. Highly expressed in a number of tumors cells lines, such ovarian, colon, breast, lung and renal cells lines. Initially described as being exclusively transcribed in the epididymis. {ECO:0000269|PubMed:15781627}.
|
![Western Blot: HE4 Overexpression Lysate (Adult Normal) [NBL1-17841] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for HE4.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/7319_HE4%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-17841-img0002.jpg)