Gene Symbol | WFDC2 |
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Entrez Gene | 10406 |
Alt Symbol | EDDM4, HE4, WAP5, dJ461P17.6 |
Species | Human |
Gene Type | protein-coding |
Description | WAP four-disulfide core domain 2 |
Other Description | WAP domain containing protein HE4-V4|WAP four-disulfide core domain protein 2|epididymal protein 4|epididymal secretory protein E4|epididymis-specific, whey-acidic protein type, four-disulfide core|major epididymis-specific protein E4|putative protease inhibitor WAP5 |
Swissprots | Q96KJ1 Q8WXW2 Q6IB27 Q8WXV9 A2A2A5 A2A2A6 Q8WXW0 A6PVD5 Q14508 Q8WXW1 |
Accessions | CAV31701 CAV31702 CAY39341 EAW75836 EAW75837 EAW75838 EAW75839 EAW75840 Q14508 AF330259 AAL37485 AF330260 AAL37486 AF330261 AAL37487 AF330262 AAL37488 AK225528 AK290288 BAF82977 AK311966 AY212888 AAO52683 BC039816 BC046106 AAH46106 BI759775 CR456977 CAG33258 EU831749 ACE87267 EU831825 ACE86584 HQ448483 ADQ32963 X63187 CAA44869 XM_011528495 XP_011526797 NM_006103 NP_006094 NM_080733 NM_080734 NM_080735 NM_080736 |
Function | Broad range protease inhibitor. {ECO:0000269|PubMed:23139753}. |
Subcellular Location | Secreted {ECO:0000269|PubMed:15781627, ECO:0000269|PubMed:23139753}. |
Tissue Specificity | Expressed in a number of normal tissues, including male reproductive system, regions of the respiratory tract and nasopharynx. Highly expressed in a number of tumors cells lines, such ovarian, colon, breast, lung and renal cells lines. Initially described as being exclusively transcribed in the epididymis. {ECO:0000269|PubMed:15781627}. |
HE4 CRISPR/Cas9 KO Plasmid (h) - sc-402876 from Santa Cruz Biotechnology
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HE4 HDR Plasmid (h) - sc-402876-HDR from Santa Cruz Biotechnology
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HE4 Double Nickase Plasmid (h) - sc-402876-NIC from Santa Cruz Biotechnology
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HE4 Double Nickase Plasmid (h2) - sc-402876-NIC-2 from Santa Cruz Biotechnology
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HE4 CRISPR Activation Plasmid (h) - sc-402876-ACT from Santa Cruz Biotechnology
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HE4 CRISPR Activation Plasmid (h2) - sc-402876-ACT-2 from Santa Cruz Biotechnology
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HE4 Lentiviral Activation Particles (h) - sc-402876-LAC from Santa Cruz Biotechnology
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HE4 Lentiviral Activation Particles (h2) - sc-402876-LAC-2 from Santa Cruz Biotechnology
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HE4 siRNA (h) - sc-43826 from Santa Cruz Biotechnology
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HE4 shRNA Plasmid (h) - sc-43826-SH from Santa Cruz Biotechnology
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HE4 shRNA (h) Lentiviral Particles - sc-43826-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU124541 from Sigma-Aldrich
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MISSION® esiRNA - EHU094991 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22883 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22883 from Sigma-Aldrich
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WFDC2 siRNA (Human) - CRH7054 from Cohesion Biosciences
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HE4/WFDC2 RNAi - H00010406-R01 from Novus Biologicals
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WFDC2 - MBS8210608 from MyBioSource
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shRNA set against Human WFDC2 (NM_006103.3) - SHH446836 from Creative biogene
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shRNA set against Human WFDC2(NM_006103.3) - SHL131914 from Creative biogene
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WFDC2 shRNA Plasmid (Human) - CHH7054 from Cohesion Biosciences
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WFDC2 miRNA 3'UTR clone - MiUTR1H-11253 from Creative biogene
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