| Gene Symbol |
HERC5
|
| Entrez Gene |
51191
|
| Alt Symbol |
CEB1, CEBP1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
HECT and RLD domain containing E3 ubiquitin protein ligase 5
|
| Other Description |
E3 ISG15--protein ligase HERC5|HECT domain and RCC1-like domain-containing protein 5|cyclin-E-binding protein 1|hect domain and RLD 5|probable E3 ubiquitin-protein ligase HERC5
|
| Swissprots |
Q69G20 B2RTQ1 Q9UII4
|
| Accessions |
EAX06020 Q9UII4 AB027289 BAA88519 AI336946 AK093155 BAG52666 AK301756 BAG63217 AK302142 BAG63515 AV657231 AY337518 AAR00320 BC140716 AAI40717 XM_011532022 XP_011530324 XM_011532023 XP_011530325 NM_016323 NP_057407
|
| Function |
Major E3 ligase for ISG15 conjugation. Acts as a positive regulator of innate antiviral response in cells induced by interferon. Functions as part of the ISGylation machinery that recognizes target proteins in a broad and relatively non-specific manner. Catalyzes ISGylation of IRF3 which results in sustained activation, it attenuates IRF3-PIN1 interaction, which antagonizes IRF3 ubiquitination and degradation, and boosts the antiviral response. Catalyzes ISGylation of influenza A viral NS1 which attenuates virulence; ISGylated NS1 fails to form homodimers and thus to interact with its RNA targets. Catalyzes ISGylation of papillomavirus type 16 L1 protein which results in dominant- negative effect on virus infectivity. Physically associated with polyribosomes, broadly modifies newly synthesized proteins in a cotranslational manner. In an interferon-stimulated cell, newly translated viral proteins are primary targets of ISG15. {ECO:0000269|PubMed:16407192, ECO:0000269|PubMed:16815975, EC
|
| Subcellular Location |
Cytoplasm, perinuclear region {ECO:0000269|PubMed:20542004}. Note=Associated with the polyribosomes, probably via the 60S subunit.
|
| Tissue Specificity |
Expressed in testis and to a lesser degree in brain, ovary and placenta. Found in most tissues at low levels. {ECO:0000269|PubMed:10581175, ECO:0000269|PubMed:15331633}.
|