HERC5

Gene Symbol HERC5
Entrez Gene 51191
Alt Symbol CEB1, CEBP1
Species Human
Gene Type protein-coding
Description HECT and RLD domain containing E3 ubiquitin protein ligase 5
Other Description E3 ISG15--protein ligase HERC5|HECT domain and RCC1-like domain-containing protein 5|cyclin-E-binding protein 1|hect domain and RLD 5|probable E3 ubiquitin-protein ligase HERC5
Swissprots Q69G20 B2RTQ1 Q9UII4
Accessions EAX06020 Q9UII4 AB027289 BAA88519 AI336946 AK093155 BAG52666 AK301756 BAG63217 AK302142 BAG63515 AV657231 AY337518 AAR00320 BC140716 AAI40717 XM_011532022 XP_011530324 XM_011532023 XP_011530325 NM_016323 NP_057407
Function Major E3 ligase for ISG15 conjugation. Acts as a positive regulator of innate antiviral response in cells induced by interferon. Functions as part of the ISGylation machinery that recognizes target proteins in a broad and relatively non-specific manner. Catalyzes ISGylation of IRF3 which results in sustained activation, it attenuates IRF3-PIN1 interaction, which antagonizes IRF3 ubiquitination and degradation, and boosts the antiviral response. Catalyzes ISGylation of influenza A viral NS1 which attenuates virulence; ISGylated NS1 fails to form homodimers and thus to interact with its RNA targets. Catalyzes ISGylation of papillomavirus type 16 L1 protein which results in dominant- negative effect on virus infectivity. Physically associated with polyribosomes, broadly modifies newly synthesized proteins in a cotranslational manner. In an interferon-stimulated cell, newly translated viral proteins are primary targets of ISG15. {ECO:0000269|PubMed:16407192, ECO:0000269|PubMed:16815975, EC
Subcellular Location Cytoplasm, perinuclear region {ECO:0000269|PubMed:20542004}. Note=Associated with the polyribosomes, probably via the 60S subunit.
Tissue Specificity Expressed in testis and to a lesser degree in brain, ovary and placenta. Found in most tissues at low levels. {ECO:0000269|PubMed:10581175, ECO:0000269|PubMed:15331633}.

Herc5 (C-17) - sc-55837 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Herc5 (C-17): sc-55837. Immunoperoxidase staining of formalin fixed, paraffin-embedded human testis tissue showing cytoplasmic staining of cells in seminiferous ducts and cytoplasmic and nuclear staining of Leydig cells and Myoid cells.

Anti-HECT E3 ubiquitin ligase antibody - ab83853 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human pineal tissue labelling HECT E3 ubiquitin ligase with ab83853 at 1/100. A Cy3-conjugated donkey anti-rabbit IgG (1/200) was used as the secondary antibody. Positive staining shown in the cytoplasm of cell bodies and processes of pinealocytes. Magnification: 20X. Exposure time: 0.5 - 2.0 seconds. Left - DAPI. Middle - HECT E3 ubiquitin ligase. Right - Merge.

Anti-HECT E3 ubiquitin ligase antibody - ab90146 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-HECT E3 ubiquitin ligase antibody (ab90146) at 1 µg/ml (in 5% skim milk / PBS buffer) + HT1080 cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-CEB1 / HERC5 Antibody (aa900-949) IHC-plus™ - LS-B9697 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-CEB1 / HERC5 antibody IHC staining of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B9697 concentration 5 ug/ml.

Anti-CEB1 / HERC5 Antibody - LS-C343771 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western blot detection of Herc5 in Herc5 transfected 293T cell lysate (1) and IFN stimulated 293T cell lysate (2: -IFN; 3: +IFN) using BML-PW0920 at 1:1000 dilution.

Anti-CEB1 / HERC5 Antibody (aa287-336) - LS-C110768 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
HERC5 antibody LS-C110768 Western blot of HT1080 cell lysate.

HERC5 Antibody - NBP1-58102 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

HERC5 Antibody - NBP1-91985 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: HERC5 Antibody [NBP1-91985] Staining of human testis shows strong cytoplasmic positivity in the spermatogonia.

HERC5 Antibody - NBP1-58101 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: HERC5 Antibody [NBP1-58101] - Titration: 0.2-1 ug/ml, Positive Control: HT1080 cell lysate.

HERC5 Antibody - H00051191-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

HECT E3 ubiquitin ligase Antibody - bs-15445R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit

Anti-HERC5, (N-terminal) antibody produced in rabbit - SAB2103802 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-HERC5, antibody produced in rabbit: <B>Cat. No. SAB2103802</B>: Immunoblotting analysis of HERC5 in HT1080 cell lysate with HERC5 anitbody at 1 μg/mL.

Anti-HERC5 antibody produced in rabbit - SAB2101030 from Sigma-Aldrich

Prices $347.50
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-HERC5: <B>Cat. No.SAB2101030</B>: HERC5 in HepG2 cell lysate with HERC5 antibody at 1.0 μg/mL.

Anti-HERC5 antibody produced in rabbit - HPA043929 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-HERC5: <B>Cat. No. HPA043929</B>: Immunohistochemical staining of human testis shows strong cytoplasmic positivity in the spermatogonia.

HERC5 antibody - N-terminal region (ARP43212_P050) - ARP43212_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

HERC5 antibody - middle region (ARP43213_P050) - ARP43213_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

HERC5 antibody, Internal - GTX46920 from GeneTex

Prices $319.00
Sizes 50 μg
Host Rabbit
Clonality Polyclonal
Anti-HERC5 antibody, Internal used in IHC (Formalin-fixed paraffin-embedded sections). GTX46920

HERC5 antibody, N-term - GTX46921 from GeneTex

Prices $299.00
Sizes 50 μg
Host Rabbit
Clonality Polyclonal
Anti-HERC5 antibody, N-term used in Western blot. GTX46921

HERC5 antibody - 70R-5525 from Fitzgerald

Prices $345.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

HERC5 antibody - 70R-5524 from Fitzgerald

Prices $345.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Rabbit Anti-HECT E3 ubiquitin ligase Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-15445R-A350 from Bioss

Prices $325.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Rabbit Anti-HECT E3 ubiquitin ligase Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-15445R-A488 from Bioss

Prices $325.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Rabbit Anti-HECT E3 ubiquitin ligase Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-15445R-A555 from Bioss

Prices $325.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Rabbit Anti-HECT E3 ubiquitin ligase Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-15445R-A647 from Bioss

Prices $325.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Rabbit Anti-HECT E3 ubiquitin ligase Polyclonal Antibody, Cy3 Conjugated - bs-15445R-Cy3 from Bioss

Prices $345.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Search more