HERC5

Gene Symbol	HERC5
Entrez Gene	51191
Alt Symbol	CEB1, CEBP1
Species	Human
Gene Type	protein-coding
Description	HECT and RLD domain containing E3 ubiquitin protein ligase 5
Other Description	E3 ISG15--protein ligase HERC5|HECT domain and RCC1-like domain-containing protein 5|cyclin-E-binding protein 1|hect domain and RLD 5|probable E3 ubiquitin-protein ligase HERC5
Swissprots	Q69G20 B2RTQ1 Q9UII4
Accessions	EAX06020 Q9UII4 AB027289 BAA88519 AI336946 AK093155 BAG52666 AK301756 BAG63217 AK302142 BAG63515 AV657231 AY337518 AAR00320 BC140716 AAI40717 XM_011532022 XP_011530324 XM_011532023 XP_011530325 NM_016323 NP_057407
Function	Major E3 ligase for ISG15 conjugation. Acts as a positive regulator of innate antiviral response in cells induced by interferon. Functions as part of the ISGylation machinery that recognizes target proteins in a broad and relatively non-specific manner. Catalyzes ISGylation of IRF3 which results in sustained activation, it attenuates IRF3-PIN1 interaction, which antagonizes IRF3 ubiquitination and degradation, and boosts the antiviral response. Catalyzes ISGylation of influenza A viral NS1 which attenuates virulence; ISGylated NS1 fails to form homodimers and thus to interact with its RNA targets. Catalyzes ISGylation of papillomavirus type 16 L1 protein which results in dominant- negative effect on virus infectivity. Physically associated with polyribosomes, broadly modifies newly synthesized proteins in a cotranslational manner. In an interferon-stimulated cell, newly translated viral proteins are primary targets of ISG15. {ECO:0000269|PubMed:16407192, ECO:0000269|PubMed:16815975, EC
Subcellular Location	Cytoplasm, perinuclear region {ECO:0000269|PubMed:20542004}. Note=Associated with the polyribosomes, probably via the 60S subunit.
Tissue Specificity	Expressed in testis and to a lesser degree in brain, ovary and placenta. Found in most tissues at low levels. {ECO:0000269|PubMed:10581175, ECO:0000269|PubMed:15331633}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• Cell/Tissue/Blood Products

Human HECT E3 ubiquitin ligase protein fragment - ab162453 from Abcam Category Protein Source Wheat germ Species Human

Human HECT E3 ubiquitin ligase protein fragment - ab180352 from Abcam Category Protein Source E. coli Species Human

CEB1 / HERC5 Antibody Blocking Peptide - LS-E15903 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HERC5 Partial Recombinant Protein - H00051191-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

HERC5 Blocking Peptide - 33R-2921 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

HERC5 Blocking Peptide - 33R-1749 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

HERC5 protein (His tag) - 80R-3804 from Fitzgerald Category Protein Prices $275.00 Sizes 100 µg Source E.coli

HERC5 (681-1024, His-tag) - AR51491PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

HERC5 (681-1024, His-tag) - AR51491PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

HERC5 - H00051191-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

HERC5 - H00051191-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

HERC5, 681-1024aa, Human, His tag, E.coli - 01-P2671 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

HERC5 fusion protein - ag18648 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

HERC5 fusion protein - ag18449 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human HERC5, His-tagged - HERC5-178H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human E3 ISG15--protein ligase HERC5(HERC5) ,partial - CSB-YP883435HU CSB-EP883435HU CSB-BP883435HU CSB-MP883435HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

HERC5, 681-1024aa, Human, His tag, E.coli (Denatured) - ATGP2671 from ATGen Category Protein Prices $80.00, $240.00, $720.00 Sizes 20 µg, 100 µg, 500 µg Species Human

HERC5 enzyme - orb259731 from Biorbyt Category Protein Prices $230.00, $442.00 Sizes 5 μg, 20 μg Species Human

HERC5 Protein - NBP1-91985PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

HERC5 Peptide, Human - M34GP06945H from Creative Peptides Category Peptide Source Synthetic. Species Human

Recombinant Human HERC5 Protein - NBP2-51684 from Novus Biologicals Category Protein Prices $259.00, $759.00 Sizes 100 µg, 500 µg Source E. coli Species Human

HECT and RLD Domain Containing E3 Ubiquitin Protein Ligase 5, Human Recombinant - 228-20744-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Species Human

HERC5 - PAT-82670-1 from Nordic BioSite Category Protein Species Human

HERC5 - PAT-82670-2 from Nordic BioSite Category Protein Species Human

E3 ISG15--protein ligase HERC5 (HERC5), partial, Recombinant Protein - MBS1373291 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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