LATS1

Gene Symbol	LATS1
Entrez Gene	9113
Alt Symbol	WARTS, wts
Species	Human
Gene Type	protein-coding
Description	large tumor suppressor kinase 1
Other Description	LATS (large tumor suppressor, Drosophila) homolog 1|LATS, large tumor suppressor, homolog 1|WARTS protein kinase|h-warts|large tumor suppressor homolog 1|serine/threonine-protein kinase LATS1
Swissprots	Q6PKD0 O95835
Accessions	EAW47792 O95835 AF104413 AAD16882 AF164041 AAD50272 AK310422 AW021064 BC002767 AAH02767 BC015665 AAH15665 XM_006715603 XP_006715666 XM_011536250 XP_011534552 XM_011536251 XP_011534553 XM_011536252 XP_011534554 NM_001270519 NP_001257448 NM_004690 NP_004681 NR_073033
Function	Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M transition by down-regulating CDK1 kinase activity. Involved in the control of p53 expression. Affects cytokinesis by regulating actin polymerization through negativ
Subcellular Location	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:10518011}. Note=Localizes to the centrosomes throughout interphase but migrates to the mitotic apparatus, including spindle pole bodies, mitotic spindle, and midbody, during mitosis.
Tissue Specificity	Expressed in all adult tissues examined except for lung and kidney. {ECO:0000269|PubMed:10518011}.
Top Pathways	Hippo signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Phospho-LATS1 (Thr1079) (D57D3) Rabbit mAb - 8654 from Cell Signaling Technology Prices $287.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone D57D3

Phospho-LATS1 (Ser909) Antibody - 9157 from Cell Signaling Technology Prices $287.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Polyclonal

LATS1 Antibody - 9153 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Polyclonal

LATS1 (C66B5) Rabbit mAb - 3477 from Cell Signaling Technology Prices $99.00, $246.00 Sizes 20 µl (2 western blots), 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone C66B5

Phospho-LATS1 (Thr1079) Antibody - 9159 from Cell Signaling Technology Host Rabbit Clonality Polyclonal

LATS1 (G-12) - sc-398560 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

LATS1 (G-16) - sc-12494 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

LATS1 (N-18) - sc-9388 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

LATS1 (H-300) - sc-28223 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Anti-LATS1 antibody - ab85893 from Abcam Host Rabbit Clonality Polyclonal

Anti-LATS1 antibody - ab70562 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-LATS1 antibody - ab169069 from Abcam Prices $359.00 Sizes 50 µl Host Mouse Clonality Polyclonal

Anti-LATS1 antibody - ab111206 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-LATS1 Antibody (aa1-30, AP) - LS-C215567 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-LATS1 Antibody (aa1-30, APC) - LS-C215568 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-LATS1 Antibody (aa1-30, Biotin) - LS-C215569 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-LATS1 Antibody (aa1-30, FITC) - LS-C215570 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-LATS1 Antibody (aa1-30, PE) - LS-C215572 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-LATS1 Antibody (aa1-30, Azide-free, HRP) - LS-C215571 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-LATS1 Antibody (aa1-30) - LS-C322599 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-LATS1 Antibody (aa521-620) - LS-C308722 from LifeSpan Bioscience Prices $455.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-LATS1 Antibody - LS-C340904 from LifeSpan Bioscience Prices $385.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-LATS1 Antibody (aa971-1020) - LS-C107826 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-LATS1 Antibody (aa50-100) - LS-C287359 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-LATS1 Antibody - LS-C334986 from LifeSpan Bioscience Prices $305.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

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