LATS1

Gene Symbol	LATS1
Entrez Gene	9113
Alt Symbol	WARTS, wts
Species	Human
Gene Type	protein-coding
Description	large tumor suppressor kinase 1
Other Description	LATS (large tumor suppressor, Drosophila) homolog 1|LATS, large tumor suppressor, homolog 1|WARTS protein kinase|h-warts|large tumor suppressor homolog 1|serine/threonine-protein kinase LATS1
Swissprots	Q6PKD0 O95835
Accessions	EAW47792 O95835 AF104413 AAD16882 AF164041 AAD50272 AK310422 AW021064 BC002767 AAH02767 BC015665 AAH15665 XM_006715603 XP_006715666 XM_011536250 XP_011534552 XM_011536251 XP_011534553 XM_011536252 XP_011534554 NM_001270519 NP_001257448 NM_004690 NP_004681 NR_073033
Function	Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M transition by down-regulating CDK1 kinase activity. Involved in the control of p53 expression. Affects cytokinesis by regulating actin polymerization through negativ
Subcellular Location	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:10518011}. Note=Localizes to the centrosomes throughout interphase but migrates to the mitotic apparatus, including spindle pole bodies, mitotic spindle, and midbody, during mitosis.
Tissue Specificity	Expressed in all adult tissues examined except for lung and kidney. {ECO:0000269|PubMed:10518011}.
Top Pathways	Hippo signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human LATS1 protein fragment - ab125612 from Abcam Category Protein Prices $239.00 Sizes 5 µg Source Baculovirus infected sf9 cells Species Human

Human LATS1 protein fragment - ab160341 from Abcam Category Protein Source Wheat germ Species Human

LATS1 Antibody Blocking Peptide - LS-E21325 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

LATS1 Antibody Blocking Peptide - LS-E8626 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human LATS1 Protein - H00009113-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

LATS1 Peptide - P2125 from Novus Biologicals Category Peptide Species Human

LATS1-Antibody-N-term-Blocking-Peptide - BP7035a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

LATS1 Blocking Peptide - 33R-4095 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

LATS1 Blocking Peptide - abx064226 from Abbexa Category Peptide Species Human, Mouse, Rat, Monkey

LATS1 - H00009113-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

LATS1 - H00009113-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

LATS1 - P5573 from Acris Antibodies Category Protein Prices $790.00 Sizes 5 µg Species Human

LATS1 fusion protein - Ag11140 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

LATS1 fusion protein - ag10709 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human LATS1 (Active), GST-tagged - LATS1-1423H from Creative Biomart Category Protein Source Sf9 Cells Species Human

LATS1 Blocking Peptide - CBP3032 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Monkey

Recombinant Human Serine/threonine-protein kinase LATS1(LATS1) ,partial - CSB-YP012769HU CSB-EP012769HU CSB-BP012769HU CSB-MP012769HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

LATS1/2 Blocking Peptide - abx061790 from Abbexa Category Peptide

LATS1 Recombinant Protein Antigen - NBP1-86860PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

LATS1 Peptide, Human - M34GP08560H from Creative Peptides Category Peptide Source Synthetic. Species Human

LATS1/2 Blocking Peptide - CBP7180 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

LATS1, Recombinant Protein - MBS515523 from MyBioSource Category Protein Prices $290.00, $375.00 Sizes 5 µg, 10 µg Source Sf9 insect cells using baculovirus Species Human

Serine/threonine-protein kinase LATS1 (LATS1), partial, Recombinant Protein - MBS1099746 from MyBioSource Category Protein Prices $1,200.00, $1,200.00, $1,425.00, $1,425.00, $1,910.00, $1,910.00, $2,365.00, $2,365.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

LATS1/2 peptide - orb339397 from Biorbyt Category Peptide

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