| Gene Symbol |
LATS1
|
| Entrez Gene |
9113
|
| Alt Symbol |
WARTS, wts
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
large tumor suppressor kinase 1
|
| Other Description |
LATS (large tumor suppressor, Drosophila) homolog 1|LATS, large tumor suppressor, homolog 1|WARTS protein kinase|h-warts|large tumor suppressor homolog 1|serine/threonine-protein kinase LATS1
|
| Swissprots |
Q6PKD0 O95835
|
| Accessions |
EAW47792 O95835 AF104413 AAD16882 AF164041 AAD50272 AK310422 AW021064 BC002767 AAH02767 BC015665 AAH15665 XM_006715603 XP_006715666 XM_011536250 XP_011534552 XM_011536251 XP_011534553 XM_011536252 XP_011534554 NM_001270519 NP_001257448 NM_004690 NP_004681 NR_073033
|
| Function |
Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M transition by down-regulating CDK1 kinase activity. Involved in the control of p53 expression. Affects cytokinesis by regulating actin polymerization through negativ
|
| Subcellular Location |
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:10518011}. Note=Localizes to the centrosomes throughout interphase but migrates to the mitotic apparatus, including spindle pole bodies, mitotic spindle, and midbody, during mitosis.
|
| Tissue Specificity |
Expressed in all adult tissues examined except for lung and kidney. {ECO:0000269|PubMed:10518011}.
|
| Top Pathways |
Hippo signaling pathway
|
