PSMA7

Gene Symbol	PSMA7
Entrez Gene	5688
Alt Symbol	C6, HSPC, RC6-1, XAPC7
Species	Human
Gene Type	protein-coding
Description	proteasome (prosome, macropain) subunit, alpha type, 7
Other Description	proteasome subunit RC6-1\|proteasome subunit XAPC7\|proteasome subunit alpha 4\|proteasome subunit alpha type-7
Swissprots	B2R515 Q9H4K5 O14818 Q5JXJ2 Q9UEU8 Q9BR53
Accessions	CBF59525 CBU84769 EAW75398 EAW75399 EAW75400 O14818 AF022815 AAB81515 AF054185 AAC99402 AK127210 AK312025 BAG34962 BC001895 BC004427 AAH04427 BC014999 AAH14999 BG575009 BI258951 BI906714 BT007165 AAP35829 BU632089 BU687782 DQ890589 ABM92206 DQ893754 ABM84680 HY039591 NM_002792 NP_002783 NM_152255
Function	The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Plays an important role in the regulation of cell proliferation or cell cycle control, transcriptional regulation, immune and stress response, cell differentiation, and apoptosis. Interacts with some important proteins involved in transcription factor regulation, cell cycle transition, viral replication and even tumor initiation and progression. Inhibits the transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions. The interaction with EMAP2 increases the proteasome-mediated HIF-1A degradation under the hypoxic conditions. Plays a role in hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the androgen receptor (AR) and thereby enhances androgen
Subcellular Location	Cytoplasm. Nucleus.
Top Pathways	Proteasome

20S Proteasome α7 (GH6) - sc-100456 from Santa Cruz Biotechnology

Prices	$295.00
Sizes	100 µg/ml
Host	Mouse
Clonality	Monoclonal

20S Proteasome α7 (GH6): sc-100456. Western blot analysis of 20S Proteasome α7 expression in human omentum, serous carcinoma tissue extract.

20S Proteasome α7 (MCP72) - sc-58417 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	100 µl partially purified ascites
Host	Mouse
Clonality	Monoclonal

20S Proteasome α7 (MCP72): sc-58417. Western blot analysis of 20S Proteasome α7 expression in HeLa (A) and Hep G2 (B) whole cell lysates and HeLa nuclear extract (C).

20S Proteasome α7/α8 (FL-248) - sc-67344 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

20S Proteasome α7/α8 (FL-248): sc-67344. Western blot analysis of 20S Proteasome α7 expression in non-transfected 293T: sc-117752 (A), mouse 20S Proteasome α7 transfected 293T: sc-126313 (B) and PC-12 (C) whole cell lysates.

20S Proteasome α7/α8 (S-17) - sc-54727 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

20S Proteasome α7/α8 (B-4) - sc-166761 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Mouse
Clonality	Monoclonal

20S Proteasome α7/α8 (B-4): sc-166761. Western blot analysis of 20S Proteasome α7/α8 expression in Hep G2 (A) and MCF7 (B) whole cell lysates.

20S Proteasome α7/α8 (T-19) - sc-54728 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

20S Proteasome α7/α8 (T-19): sc-54728. Western blot analysis of 20S Proteasome α7/α8 expression in WI 38 (A), A549 (B), HeLa (C), PC-12 (D) and Hep G2 (E) whole cell lysates and mouse brain tissue extract (F).

Anti-PSMA7 antibody - ab55626 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal

PSMA7 antibody (ab55626) used in immunofluorescence at 1-5ug/ml on HeLa cells.

Anti-PSMA7 antibody - ab118350 from Abcam

Prices	$370.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-PSMA7 antibody (ab118350) at 1/1000 dilution + Mouse intestine lysate at 50 µg/ml

Anti-PSMA7 antibody - ab93220 from Abcam

Prices	$359.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-PSMA7 antibody (ab93220) at 1/100 dilution + Mouse spleen tissue lysate at 35 µg

Anti-PSMA7 antibody - ab88977 from Abcam

Prices	$370.00
Sizes	50 µl
Host	Mouse
Clonality	Polyclonal

Anti-PSMA7 antibody (ab88977) at 1/500 dilution + Human liver lysate at 50 µg

Anti-PSMA7 antibody [EPR5836] - ab133502 from Abcam

Prices	$313.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR5836

All lanes : Anti-PSMA7 antibody [EPR5836] (ab133502) at 1/1000 dilutionLane 1 : A549 cell lysateLane 2 : MCF7 cell lysateLane 3 : 293T cell lysateLane 4 : HeLa cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-PSMA7 antibody [EPR5837] - ab109378 from Abcam

Prices	$357.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR5837

All lanes : Anti-PSMA7 antibody [EPR5837] (ab109378) at 1/10000 dilutionLane 1 : MCF7 cell lysateLane 2 : HeLa cell lysateLane 3 : HepG2 cell lysateLane 4 : A549 cell lysateLysates/proteins at 10 µg per lane.

Anti-PSMA7 Antibody (clone 8F9) - LS-C114783 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	8F9

IHC of paraffin-embedded prostate tissue using anti-PSMA7 mouse monoclonal antibody. (Dilution 1:50).

Anti-PSMA7 Antibody (clone 1A10-3G12) IHC-plus™ - LS-B9946 from LifeSpan Bioscience

Prices	$395.00
Sizes	50 µg
Host	Mouse
Clonality	Monoclonal
Clone	1A10-3G12

Anti-PSMA7 / HSPC antibody IHC staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B9946 concentration 20 ug/ml.

Anti-PSMA7 Antibody (Biotin) - LS-C183255 from LifeSpan Bioscience

Prices	$425.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Anti-PSMA7 Antibody (FITC) - LS-C183256 from LifeSpan Bioscience

Prices	$425.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Anti-PSMA7 Antibody (HRP) - LS-C183257 from LifeSpan Bioscience

Prices	$425.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Anti-PSMA7 Antibody - LS-C190014 from LifeSpan Bioscience

Prices	$425.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Anti-PSMA7 Antibody (clone 5E3) - LS-C114780 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	5E3

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PSMA7 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PSMA7.

Anti-PSMA7 Antibody (Internal, clone EPR5836) - LS-C138656 from LifeSpan Bioscience

Prices	$395.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR5836

IHC of paraffin-embedded human breast carcinoma tissue using anti-PSMA7 antibody.

Anti-PSMA7 Antibody (Internal, clone EPR5837) - LS-C138541 from LifeSpan Bioscience

Prices	$450.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR5837

IHC of paraffin-embedded human kidney carcinoma tissue using anti-PSMA7 antibody.

Anti-PSMA7 Antibody (HRP) - LS-C211125 from LifeSpan Bioscience

Prices	$315.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Western blot of Proteasome subunit alpha type-7 antibody at 2 ug/ml. Lane 1:293T whole cell lysate. Lane 2: EC109whole cell lysate. Secondary: Goat polyclonal to Rabbit IgG at 1:15000 dilution. Predicted band size: 27 kDa. Observed band size: 27 kDa.

Anti-PSMA7 Antibody (FITC) - LS-C211126 from LifeSpan Bioscience

Prices	$315.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-PSMA7 Antibody - LS-C211123 from LifeSpan Bioscience

Prices	$315.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-PSMA7 Antibody (Biotin) - LS-C211127 from LifeSpan Bioscience

Prices	$315.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

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