Gene Symbol | PSMA7 |
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Entrez Gene | 5688 |
Alt Symbol | C6, HSPC, RC6-1, XAPC7 |
Species | Human |
Gene Type | protein-coding |
Description | proteasome (prosome, macropain) subunit, alpha type, 7 |
Other Description | proteasome subunit RC6-1|proteasome subunit XAPC7|proteasome subunit alpha 4|proteasome subunit alpha type-7 |
Swissprots | B2R515 Q9H4K5 O14818 Q5JXJ2 Q9UEU8 Q9BR53 |
Accessions | CBF59525 CBU84769 EAW75398 EAW75399 EAW75400 O14818 AF022815 AAB81515 AF054185 AAC99402 AK127210 AK312025 BAG34962 BC001895 BC004427 AAH04427 BC014999 AAH14999 BG575009 BI258951 BI906714 BT007165 AAP35829 BU632089 BU687782 DQ890589 ABM92206 DQ893754 ABM84680 HY039591 NM_002792 NP_002783 NM_152255 |
Function | The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Plays an important role in the regulation of cell proliferation or cell cycle control, transcriptional regulation, immune and stress response, cell differentiation, and apoptosis. Interacts with some important proteins involved in transcription factor regulation, cell cycle transition, viral replication and even tumor initiation and progression. Inhibits the transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions. The interaction with EMAP2 increases the proteasome-mediated HIF-1A degradation under the hypoxic conditions. Plays a role in hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the androgen receptor (AR) and thereby enhances androgen |
Subcellular Location | Cytoplasm. Nucleus. |
Top Pathways | Proteasome |
Human PSMA7 full length protein - ab81381 from Abcam
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Human PSMA7 full length protein - ab116477 from Abcam
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PSMA7 Antibody Blocking Peptide - LS-E9707 from LifeSpan Bioscience
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PSMA7 Recombinant Protein - H00005688-P01 from Novus Biologicals
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PSMA7 Protein - NBC1-22917 from Novus Biologicals
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PSMA7-Antibody-Center-Blocking-Peptide - BP8659c from Abgent, a WuXi AppTec company
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Recombinant human Proteasome subunit alpha type-7 (OPCA00383) - OPCA00383 from Aviva Systems Biology
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PSMA7 Protein (OPPA01923) - OPPA01923 from Aviva Systems Biology
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Human PSMB7 protein - orb245076 from Biorbyt
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Human HSPC protein - orb245075 from Biorbyt
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Human PSMA7 protein - orb90252 from Biorbyt
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PSMA7 protein (His tag) - 80R-1098 from Fitzgerald
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PSMA7 (1-248, His-tag) - AR50030PU-N from Acris Antibodies
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PSMA7 (1-248, His-tag) - AR50030PU-S from Acris Antibodies
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PSMA7 - H00005688-P01-10 from Acris Antibodies
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PSMA7 - H00005688-P01-25 from Acris Antibodies
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Proteasome Subunit Alpha Type 7, Human Recombinant - 228-11333-1 from RayBiotech
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Recombinant Human PSMA7 - 228-11333-2 from RayBiotech
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Recombinant Human PSMA7 - 228-11333-3 from RayBiotech
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PSMA7, 1-248aa, Human, His-tagged, Recombinant, E.coli - 01-2011 from ARP American Research Products
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PSMA7 fusion protein - Ag7389 from Proteintech Group
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PSMA7 fusion protein - Ag7821 from Proteintech Group
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PSMA7 Human - ENPS-410 from NeoScientific
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Recombinant Human Proteasome Subunit A Type 7 - BP000804-ENZ-403 from Syd Labs
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PSMA7, 1-248aa, Recombinant Protein - GWB-P0073H from Genway Biotech
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