| Gene Symbol | PSMA7 |
|---|---|
| Entrez Gene | 5688 |
| Alt Symbol | C6, HSPC, RC6-1, XAPC7 |
| Species | Human |
| Gene Type | protein-coding |
| Description | proteasome (prosome, macropain) subunit, alpha type, 7 |
| Other Description | proteasome subunit RC6-1|proteasome subunit XAPC7|proteasome subunit alpha 4|proteasome subunit alpha type-7 |
| Swissprots | B2R515 Q9H4K5 O14818 Q5JXJ2 Q9UEU8 Q9BR53 |
| Accessions | CBF59525 CBU84769 EAW75398 EAW75399 EAW75400 O14818 AF022815 AAB81515 AF054185 AAC99402 AK127210 AK312025 BAG34962 BC001895 BC004427 AAH04427 BC014999 AAH14999 BG575009 BI258951 BI906714 BT007165 AAP35829 BU632089 BU687782 DQ890589 ABM92206 DQ893754 ABM84680 HY039591 NM_002792 NP_002783 NM_152255 |
| Function | The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Plays an important role in the regulation of cell proliferation or cell cycle control, transcriptional regulation, immune and stress response, cell differentiation, and apoptosis. Interacts with some important proteins involved in transcription factor regulation, cell cycle transition, viral replication and even tumor initiation and progression. Inhibits the transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions. The interaction with EMAP2 increases the proteasome-mediated HIF-1A degradation under the hypoxic conditions. Plays a role in hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the androgen receptor (AR) and thereby enhances androgen |
| Subcellular Location | Cytoplasm. Nucleus. |
| Top Pathways | Proteasome |
20S Proteasome α7 CRISPR/Cas9 KO Plasmid (h) - sc-401897 from Santa Cruz Biotechnology
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20S Proteasome α7 HDR Plasmid (h) - sc-401897-HDR from Santa Cruz Biotechnology
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20S Proteasome α7 Double Nickase Plasmid (h) - sc-401897-NIC from Santa Cruz Biotechnology
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20S Proteasome α7 Double Nickase Plasmid (h2) - sc-401897-NIC-2 from Santa Cruz Biotechnology
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20S Proteasome α7 CRISPR Activation Plasmid (h) - sc-401897-ACT from Santa Cruz Biotechnology
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20S Proteasome α7 CRISPR Activation Plasmid (h2) - sc-401897-ACT-2 from Santa Cruz Biotechnology
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20S Proteasome α7 Lentiviral Activation Particles (h) - sc-401897-LAC from Santa Cruz Biotechnology
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20S Proteasome α7 Lentiviral Activation Particles (h2) - sc-401897-LAC-2 from Santa Cruz Biotechnology
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20S Proteasome α7 siRNA (h) - sc-62886 from Santa Cruz Biotechnology
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20S Proteasome α7 shRNA Plasmid (h) - sc-62886-SH from Santa Cruz Biotechnology
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20S Proteasome α7 shRNA (h) Lentiviral Particles - sc-62886-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU099921 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17594 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17594 from Sigma-Aldrich
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PSMA7 siRNA (Human) - CRH3835 from Cohesion Biosciences
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PSMA7 RNAi - H00005688-R01 from Novus Biologicals
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shRNA set against Human PSMA7 (NM_002792.3) - SHH385112 from Creative biogene
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PSMA7 shRNA Plasmid (Human) - CHH3835 from Cohesion Biosciences
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PSMA7 miRNA 3'UTR clone - MiUTR3H-08606 from Creative biogene
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