| Gene Symbol |
KCNJ3
|
| Entrez Gene |
3760
|
| Alt Symbol |
GIRK1, KGA, KIR3.1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
potassium channel, inwardly rectifying subfamily J, member 3
|
| Other Description |
G protein-activated inward rectifier potassium channel 1|GIRK-1|inward rectifier K(+) channel Kir3.1|inward rectifier K+ channel KIR3.1|potassium channel, inwardly rectifying subfamily J member 3|potassium inwardly-rectifying channel subfamily J member 3 splice variant 1e|potassium inwardly-rectifying channel, subfamily J, member 3
|
| Swissprots |
Q8TBI0 B4DEW7 P48549
|
| Accessions |
AAX93197 EAX11461 P48549 AK026384 AK293824 BAG57228 AK293924 BAG57305 AW949825 BC022495 AAH22495 DQ892363 ABM83289 DQ895572 ABM86498 GU068048 ADB11083 GU074515 ADB11081 GU074516 ADB11082 U50964 AAB42176 NM_001260508 NP_001247437 NM_001260509 NP_001247438 NM_001260510 NP_001247439 NM_002239 NP_002230
|
| Function |
This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat.
|
| Subcellular Location |
Membrane; Multi-pass membrane protein.
|
| Top Pathways |
Glutamatergic synapse, Dopaminergic synapse, Morphine addiction, Retrograde endocannabinoid signaling, Circadian entrainment
|