KCNJ3
| Gene Symbol | KCNJ3 |
|---|---|
| Entrez Gene | 3760 |
| Alt Symbol | GIRK1, KGA, KIR3.1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | potassium channel, inwardly rectifying subfamily J, member 3 |
| Other Description | G protein-activated inward rectifier potassium channel 1|GIRK-1|inward rectifier K(+) channel Kir3.1|inward rectifier K+ channel KIR3.1|potassium channel, inwardly rectifying subfamily J member 3|potassium inwardly-rectifying channel subfamily J member 3 splice variant 1e|potassium inwardly-rectifying channel, subfamily J, member 3 |
| Swissprots | Q8TBI0 B4DEW7 P48549 |
| Accessions | AAX93197 EAX11461 P48549 AK026384 AK293824 BAG57228 AK293924 BAG57305 AW949825 BC022495 AAH22495 DQ892363 ABM83289 DQ895572 ABM86498 GU068048 ADB11083 GU074515 ADB11081 GU074516 ADB11082 U50964 AAB42176 NM_001260508 NP_001247437 NM_001260509 NP_001247438 NM_001260510 NP_001247439 NM_002239 NP_002230 |
| Function | This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat. |
| Subcellular Location | Membrane; Multi-pass membrane protein. |
| Top Pathways | Glutamatergic synapse, Dopaminergic synapse, Morphine addiction, Retrograde endocannabinoid signaling, Circadian entrainment |
KIR3.1 CRISPR/Cas9 KO Plasmid (h) - sc-404965 from Santa Cruz Biotechnology
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KIR3.1 HDR Plasmid (h) - sc-404965-HDR from Santa Cruz Biotechnology
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KIR3.1 Double Nickase Plasmid (h) - sc-404965-NIC from Santa Cruz Biotechnology
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KIR3.1 Double Nickase Plasmid (h2) - sc-404965-NIC-2 from Santa Cruz Biotechnology
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KIR3.1 CRISPR Activation Plasmid (h) - sc-404965-ACT from Santa Cruz Biotechnology
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KIR3.1 CRISPR Activation Plasmid (h2) - sc-404965-ACT-2 from Santa Cruz Biotechnology
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KIR3.1 Lentiviral Activation Particles (h) - sc-404965-LAC from Santa Cruz Biotechnology
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KIR3.1 Lentiviral Activation Particles (h2) - sc-404965-LAC-2 from Santa Cruz Biotechnology
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KIR3.1 siRNA (h) - sc-42616 from Santa Cruz Biotechnology
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KIR3.1 shRNA Plasmid (h) - sc-42616-SH from Santa Cruz Biotechnology
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KIR3.1 shRNA (h) Lentiviral Particles - sc-42616-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU047201 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10957 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10957 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08461 from Sigma-Aldrich
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KCNJ3 siRNA (Human) - CRH2536 from Cohesion Biosciences
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Kir3.1 RNAi - H00003760-R01 from Novus Biologicals
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shRNA set against Human KCNJ3 (NM_002239.3) - SHH323287 from Creative biogene
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Human KCNJ3 siRNA - orb263038 from Biorbyt
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KCNJ3 shRNA Plasmid (Human) - CHH2536 from Cohesion Biosciences
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KCNJ3 miRNA 3'UTR clone - MiUTR3H-04197 from Creative biogene
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