POLI

Gene Symbol POLI
Entrez Gene 11201
Alt Symbol RAD30B, RAD3OB
Species Human
Gene Type protein-coding
Description polymerase (DNA directed) iota
Other Description DNA polymerase iota|RAD30 homolog B|eta2|polymerase (DNA-directed), iota
Swissprots Q9NYH6 Q9H0S1 Q8N590 Q9UNA4
Accessions AAM11872 EAW63000 EAW63001 Q9UNA4 AF140501 AAD50381 AF245438 AAF63383 AK093688 AK226057 AK301578 BAH13516 AL136670 CAB66605 AM392978 CAL37856 BC032617 BC032662 AAH32662 BM993293 BX649100 DA315805 DB450447 DQ890893 ABM81819 DQ896811 ABM87810 XM_005258188 XP_005258245 XM_005258191 XP_005258248 XM_005258192 XP_005258249 XM_006722378 XP_006722441 XM_011525796 XP_011524098 XM_011525797 XP_011524099 NM_007195 NP_009126
Function Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunogobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity. {ECO:0000269|PubMed:11013228, ECO:0000269|PubMed:11251121, ECO:0000269|PubMed:11387224, ECO:0000269|PubMed:12410315, ECO:0000269|PubMed:14630940, ECO:0000269|PubMed:15199127, ECO:0000269|PubMed:15254543}.
Subcellular Location Nucleus {ECO:0000269|PubMed:12606586}. Note=Accumulates at replication forks after DNA damage.
Tissue Specificity Ubiquitous. Highly expressed in testis. {ECO:0000269|PubMed:10458907, ECO:0000269|PubMed:11387224}.
Top Pathways Fanconi anemia pathway

POLI overexpression lysate - LY416129 from Acris Antibodies

Category Cell Lysate
Prices $480.00
Sizes 100 µg

POLI 293 Cell Lysate - 407552 from ABBIOTEC

Category Cell Lysate
Prices $672.00
Sizes 100 µg

DNA pol ι (h): 293T Lysate - sc-115254 from Santa Cruz Biotechnology

Category Cell Lysate
Prices $205.00
Sizes 100 µg/200 µl
Species Human

POLI Over-expression Lysate Product - GWB-1851A7 from Genway Biotech

Category Cell Lysate
Prices $756.00
Sizes 100 µg
Species Human

DNA Polymerase iota Overexpression Lysate (Native) - NBP2-10378 from Novus Biologicals

Category Cell Lysate
Prices $529.00
Sizes 100 µg
Western Blot: DNA Polymerase iota Overexpression Lysate (Adult Normal) [NBP2-10378] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for DNA Polymerase iota.

Panoply™ Human POLI Knockdown Stable Cell Line - CSC-DC012078 from Creative biogene

Category Cell Line
Species Human
Search more