POLI

Gene Symbol	POLI
Entrez Gene	11201
Alt Symbol	RAD30B, RAD3OB
Species	Human
Gene Type	protein-coding
Description	polymerase (DNA directed) iota
Other Description	DNA polymerase iota|RAD30 homolog B|eta2|polymerase (DNA-directed), iota
Swissprots	Q9NYH6 Q9H0S1 Q8N590 Q9UNA4
Accessions	AAM11872 EAW63000 EAW63001 Q9UNA4 AF140501 AAD50381 AF245438 AAF63383 AK093688 AK226057 AK301578 BAH13516 AL136670 CAB66605 AM392978 CAL37856 BC032617 BC032662 AAH32662 BM993293 BX649100 DA315805 DB450447 DQ890893 ABM81819 DQ896811 ABM87810 XM_005258188 XP_005258245 XM_005258191 XP_005258248 XM_005258192 XP_005258249 XM_006722378 XP_006722441 XM_011525796 XP_011524098 XM_011525797 XP_011524099 NM_007195 NP_009126
Function	Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunogobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity. {ECO:0000269|PubMed:11013228, ECO:0000269|PubMed:11251121, ECO:0000269|PubMed:11387224, ECO:0000269|PubMed:12410315, ECO:0000269|PubMed:14630940, ECO:0000269|PubMed:15199127, ECO:0000269|PubMed:15254543}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:12606586}. Note=Accumulates at replication forks after DNA damage.
Tissue Specificity	Ubiquitous. Highly expressed in testis. {ECO:0000269|PubMed:10458907, ECO:0000269|PubMed:11387224}.
Top Pathways	Fanconi anemia pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human DNA Polymerase iota full length protein - ab161348 from Abcam Category Protein Source Wheat germ Species Human

Human DNA Polymerase iota protein fragment - ab161349 from Abcam Category Protein Source Wheat germ Species Human

POLI Antibody Blocking Peptide - LS-E3352 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

POLI Antibody Blocking Peptide - LS-E18800 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human DNA Polymerase iota Protein - H00011201-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human DNA Polymerase iota Protein - H00011201-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

POLI-Antibody-C-term-Blocking-Peptide - BP14526b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

POLI Blocking Peptide - 33R-7428 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

DNA polymerase iota - H00011201-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

DNA polymerase iota - H00011201-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

DNA polymerase iota - H00011201-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

DNA polymerase iota - H00011201-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

POLI fusion protein - Ag5599 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

POLI fusion protein - Ag4563 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human POLI, His-tagged - POLI-1834H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human DNA polymerase iota(POLI) - CSB-YP892157HU CSB-EP892157HU CSB-BP892157HU CSB-MP892157HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

DNA polymerase iota - TP307550 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

DNA Polymerase iota Protein - NBP1-87164PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

POLI Peptide, Human - M34GP12078H from Creative Peptides Category Peptide Source Synthetic. Species Human

DNA Polymerase iota Recombinant Protein Antigen - NBP2-55989PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

DNA polymerase iota (POLI), Recombinant Protein - MBS1443539 from MyBioSource Category Protein Prices $1,550.00, $1,550.00, $1,780.00, $1,780.00, $2,670.00, $2,670.00, $3,110.00, $3,110.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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