| Gene Symbol |
POLI
|
| Entrez Gene |
11201
|
| Alt Symbol |
RAD30B, RAD3OB
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
polymerase (DNA directed) iota
|
| Other Description |
DNA polymerase iota|RAD30 homolog B|eta2|polymerase (DNA-directed), iota
|
| Swissprots |
Q9NYH6 Q9H0S1 Q8N590 Q9UNA4
|
| Accessions |
AAM11872 EAW63000 EAW63001 Q9UNA4 AF140501 AAD50381 AF245438 AAF63383 AK093688 AK226057 AK301578 BAH13516 AL136670 CAB66605 AM392978 CAL37856 BC032617 BC032662 AAH32662 BM993293 BX649100 DA315805 DB450447 DQ890893 ABM81819 DQ896811 ABM87810 XM_005258188 XP_005258245 XM_005258191 XP_005258248 XM_005258192 XP_005258249 XM_006722378 XP_006722441 XM_011525796 XP_011524098 XM_011525797 XP_011524099 NM_007195 NP_009126
|
| Function |
Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunogobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity. {ECO:0000269|PubMed:11013228, ECO:0000269|PubMed:11251121, ECO:0000269|PubMed:11387224, ECO:0000269|PubMed:12410315, ECO:0000269|PubMed:14630940, ECO:0000269|PubMed:15199127, ECO:0000269|PubMed:15254543}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:12606586}. Note=Accumulates at replication forks after DNA damage.
|
| Tissue Specificity |
Ubiquitous. Highly expressed in testis. {ECO:0000269|PubMed:10458907, ECO:0000269|PubMed:11387224}.
|
| Top Pathways |
Fanconi anemia pathway
|