Gene Symbol | LMCD1 |
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Entrez Gene | 29995 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | LIM and cysteine-rich domains 1 |
Other Description | LIM and cysteine-rich domains protein 1|dyxin |
Swissprots | B4DG80 Q9NZU5 |
Accessions | EAW63937 EAW63938 Q9NZU5 AF169284 AAF34411 AF216709 AAG36778 AI693011 AI951010 AK022176 BAB13976 AK074448 AK293849 BAG57247 AK294455 BAG57691 AK300803 BAH13351 BC000646 AAH00646 BU619403 BX114807 CN388104 DQ891747 ABM82673 DQ894926 ABM85852 N95437 W47274 XM_011533649 XP_011531951 NM_001278233 NP_001265162 NM_001278234 NP_001265163 NM_001278235 NP_001265164 NM_014583 NP_055398 |
Function | Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. Represses GATA6-mediated trans activation of lung- and cardiac tissue- specific promoters. Inhibits DNA-binding by GATA4 and GATA1 to the cTNC promoter (By similarity). Plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway. {ECO:0000250, ECO:0000269|PubMed:20026769}. |
Subcellular Location | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=May shuttle between the cytoplasm and the nucleus. {ECO:0000250}. |
Tissue Specificity | Expressed in the heart (at protein level). Expressed in many tissues with highest abundance in skeletal muscle. {ECO:0000269|PubMed:20026769}. |
LMCD1 (A-14) - sc-99963 from Santa Cruz Biotechnology
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LMCD1 (K-15) - sc-99964 from Santa Cruz Biotechnology
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Anti-LMCD1 antibody - ab121788 from Abcam
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Anti-LMCD1 antibody - ab167211 from Abcam
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Anti-LMCD1 antibody [1H5] - ab123923 from Abcam
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Anti-LMCD1 antibody [2G5] - ab123893 from Abcam
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Anti-LMCD1 antibody [EPR11443(B)] - ab169760 from Abcam
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Anti-LMCD1 antibody [EPR11444] - ab179454 from Abcam
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Anti-LMCD1 Antibody - LS-C308771 from LifeSpan Bioscience
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Anti-LMCD1 Antibody (clone 2G5) - LS-C337336 from LifeSpan Bioscience
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Anti-LMCD1 Antibody (clone 1H5) - LS-C337410 from LifeSpan Bioscience
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Anti-LMCD1 Antibody (clone 2F12) - LS-C172904 from LifeSpan Bioscience
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LMCD1 Antibody (1H5) - NBP2-00934 from Novus Biologicals
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LMCD1 Antibody - H00029995-B01P from Novus Biologicals
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LMCD1 Antibody - H00029995-B01 from Novus Biologicals
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LMCD1 Antibody - H00029995-A01 from Novus Biologicals
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LMCD1 Antibody - NBP1-85986 from Novus Biologicals
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LMCD1 Polyclonal Antibody - bs-11874R from Bioss
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LMCD1 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-11874R-A350 from Bioss
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LMCD1 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-11874R-A488 from Bioss
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LMCD1 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-11874R-A555 from Bioss
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LMCD1 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-11874R-A647 from Bioss
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LMCD1 Polyclonal Antibody, Cy3 Conjugated - bs-11874R-Cy3 from Bioss
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LMCD1 Polyclonal Antibody, Cy5 Conjugated - bs-11874R-Cy5 from Bioss
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LMCD1 Polyclonal Antibody, Cy5.5 Conjugated - bs-11874R-Cy5.5 from Bioss
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