| Gene Symbol | LMCD1 |
|---|---|
| Entrez Gene | 29995 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | LIM and cysteine-rich domains 1 |
| Other Description | LIM and cysteine-rich domains protein 1|dyxin |
| Swissprots | B4DG80 Q9NZU5 |
| Accessions | EAW63937 EAW63938 Q9NZU5 AF169284 AAF34411 AF216709 AAG36778 AI693011 AI951010 AK022176 BAB13976 AK074448 AK293849 BAG57247 AK294455 BAG57691 AK300803 BAH13351 BC000646 AAH00646 BU619403 BX114807 CN388104 DQ891747 ABM82673 DQ894926 ABM85852 N95437 W47274 XM_011533649 XP_011531951 NM_001278233 NP_001265162 NM_001278234 NP_001265163 NM_001278235 NP_001265164 NM_014583 NP_055398 |
| Function | Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. Represses GATA6-mediated trans activation of lung- and cardiac tissue- specific promoters. Inhibits DNA-binding by GATA4 and GATA1 to the cTNC promoter (By similarity). Plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway. {ECO:0000250, ECO:0000269|PubMed:20026769}. |
| Subcellular Location | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=May shuttle between the cytoplasm and the nucleus. {ECO:0000250}. |
| Tissue Specificity | Expressed in the heart (at protein level). Expressed in many tissues with highest abundance in skeletal muscle. {ECO:0000269|PubMed:20026769}. |
LIM and cysteine-rich domains protein 1 (LMCD1), Human, ELISA Kit - E01L0332 from ARP American Research Products
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LIM and cysteine rich domains protein 1 (LMCD1), ELISA Kit - MBS7211789 from MyBioSource
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LIM And Cysteine Rich Domains Protein 1 (LMCD1), ELISA Kit - MBS9313372 from MyBioSource
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Human LMCD1 ELISA Kit - E022697 from Biobool
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