| Gene Symbol |
LMCD1
|
| Entrez Gene |
29995
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
LIM and cysteine-rich domains 1
|
| Other Description |
LIM and cysteine-rich domains protein 1|dyxin
|
| Swissprots |
B4DG80 Q9NZU5
|
| Accessions |
EAW63937 EAW63938 Q9NZU5 AF169284 AAF34411 AF216709 AAG36778 AI693011 AI951010 AK022176 BAB13976 AK074448 AK293849 BAG57247 AK294455 BAG57691 AK300803 BAH13351 BC000646 AAH00646 BU619403 BX114807 CN388104 DQ891747 ABM82673 DQ894926 ABM85852 N95437 W47274 XM_011533649 XP_011531951 NM_001278233 NP_001265162 NM_001278234 NP_001265163 NM_001278235 NP_001265164 NM_014583 NP_055398
|
| Function |
Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. Represses GATA6-mediated trans activation of lung- and cardiac tissue- specific promoters. Inhibits DNA-binding by GATA4 and GATA1 to the cTNC promoter (By similarity). Plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway. {ECO:0000250, ECO:0000269|PubMed:20026769}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=May shuttle between the cytoplasm and the nucleus. {ECO:0000250}.
|
| Tissue Specificity |
Expressed in the heart (at protein level). Expressed in many tissues with highest abundance in skeletal muscle. {ECO:0000269|PubMed:20026769}.
|
