| Gene Symbol |
SMARCA5
|
| Entrez Gene |
8467
|
| Alt Symbol |
ISWI, SNF2H, WCRF135, hISWI, hSNF2H
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
|
| Other Description |
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5|SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5|sucrose nonfermenting protein 2 homolog|sucrose nonfermenting-like 5
|
| Swissprots |
O60264
|
| Accessions |
AAY40920 AAY40965 EAX05071 O60264 AB010882 BAA25173 AF086544 AK123439 AK302841 BAG64032 AK308424 AK316444 BAH14815 AL157495 AU132439 BC023144 AAH23144 JF432501 ADZ15718 XM_011532361 XP_011530663 NM_003601 NP_003592
|
| Function |
Helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity. Complexes containing SMARCA5 are capable of forming ordered nucleosome arrays on chromatin; this may require intact histone H4 tails. Also required for replication of pericentric heterochromatin in S-phase specifically in conjunction with BAZ1A. Probably plays a role in repression of polI dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promoter. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes. Essential component of the NoRC (nucleolar r
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00624, ECO:0000269|PubMed:12434153}.
|
| Tissue Specificity |
Ubiquitously expressed.
|