SMARCA5
| Gene Symbol | SMARCA5 |
|---|---|
| Entrez Gene | 8467 |
| Alt Symbol | ISWI, SNF2H, WCRF135, hISWI, hSNF2H |
| Species | Human |
| Gene Type | protein-coding |
| Description | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 |
| Other Description | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5|SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5|sucrose nonfermenting protein 2 homolog|sucrose nonfermenting-like 5 |
| Swissprots | O60264 |
| Accessions | AAY40920 AAY40965 EAX05071 O60264 AB010882 BAA25173 AF086544 AK123439 AK302841 BAG64032 AK308424 AK316444 BAH14815 AL157495 AU132439 BC023144 AAH23144 JF432501 ADZ15718 XM_011532361 XP_011530663 NM_003601 NP_003592 |
| Function | Helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity. Complexes containing SMARCA5 are capable of forming ordered nucleosome arrays on chromatin; this may require intact histone H4 tails. Also required for replication of pericentric heterochromatin in S-phase specifically in conjunction with BAZ1A. Probably plays a role in repression of polI dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promoter. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes. Essential component of the NoRC (nucleolar r |
| Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00624, ECO:0000269|PubMed:12434153}. |
| Tissue Specificity | Ubiquitously expressed. |
hSNF2H CRISPR/Cas9 KO Plasmid (h) - sc-403825 from Santa Cruz Biotechnology
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hSNF2H HDR Plasmid (h) - sc-403825-HDR from Santa Cruz Biotechnology
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hSNF2H Double Nickase Plasmid (h) - sc-403825-NIC from Santa Cruz Biotechnology
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hSNF2H Double Nickase Plasmid (h2) - sc-403825-NIC-2 from Santa Cruz Biotechnology
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hSNF2H CRISPR Activation Plasmid (h) - sc-403825-ACT from Santa Cruz Biotechnology
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hSNF2H CRISPR Activation Plasmid (h2) - sc-403825-ACT-2 from Santa Cruz Biotechnology
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hSNF2H Lentiviral Activation Particles (h) - sc-403825-LAC from Santa Cruz Biotechnology
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hSNF2H Lentiviral Activation Particles (h2) - sc-403825-LAC-2 from Santa Cruz Biotechnology
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hSNF2H siRNA (h) - sc-35594 from Santa Cruz Biotechnology
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hSNF2H shRNA Plasmid (h) - sc-35594-SH from Santa Cruz Biotechnology
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hSNF2H shRNA (h) Lentiviral Particles - sc-35594-V from Santa Cruz Biotechnology
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SMARCA5/SNF2H RNAi - H00008467-R02 from Novus Biologicals
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MISSION® esiRNA - EHU023611 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19763 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19763 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01726 from Sigma-Aldrich
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SMARCA5 siRNA (Human) - CRH5551 from Cohesion Biosciences
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SMARCA5 - MBS8232611 from MyBioSource
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shRNA set against Human SMARCA5 (NM_003601.3) - SHH413112 from Creative biogene
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Human SMARCA5 siRNA - orb266053 from Biorbyt
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SMARCA5 shRNA Plasmid (Human) - CHH5551 from Cohesion Biosciences
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SMARCA5 miRNA 3'UTR clone - MiUTR3H-05905 from Creative biogene
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