| Gene Symbol |
ATG4B
|
| Entrez Gene |
23192
|
| Alt Symbol |
APG4B, AUTL1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
autophagy related 4B, cysteine peptidase
|
| Other Description |
APG4 autophagy 4 homolog B|ATG4 autophagy related 4 homolog B|AUT-like 1 cysteine endopeptidase|autophagin-1|autophagy-related cysteine endopeptidase 1|autophagy-related protein 4 homolog B|cysteine protease ATG4B|hAPG4B
|
| Swissprots |
Q6ZUV8 Q53NU4 Q96SZ1 Q96K96 Q9Y2F2 Q96K07 Q8WYM9 Q9Y4P1 B7WNK2
|
| Accessions |
AAY14919 EAW71278 EAW71279 EAW71280 EAW71281 Q9Y4P1 AB023160 BAA76787 AB066215 BAB83890 AJ504652 CAD43219 AK027332 BAB55042 AK027462 BAB55127 AK027763 BAB55353 AK123425 BAG53904 AK125277 BAC86110 AK296818 BAG59391 AK298109 BAG60394 AK302963 BAG64112 AK316167 BAH14538 AL050288 AL080168 CAB45756 AL133638 AM393751 CAL38626 BC000719 AAH00719 BX648007 CAH56198 DQ891869 ABM82795 XM_005246992 XP_005247049 XM_005246993 XP_005247050 XM_005246995 XP_005247052 XM_005246996 XP_005247053 XM_011510836 XP_011509138 XM_011510837 XP_011509139 XM_011510838 XP_011509140 XM_011510839 XP_011509141 NM_013325 NP_037457 NM_178326 NP_847896
|
| Function |
Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3, GABARAPL1, GABARAPL2 and GABARAP, to reveal a C-terminal glycine. Exposure of the glycine at the C- terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms. {ECO:0000269|PubMed:15169837, ECO:0000269|PubMed:15187094, ECO:0000269|PubMed:17347651, ECO:0000269|PubMed:19322194, ECO:0000269|PubMed:21177865, ECO:0000269|PubMed:22302004}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}.
|
| Tissue Specificity |
Mainly expressed in the skeletal muscle, followed by brain, heart, liver and pancreas. {ECO:0000269|PubMed:12446702, ECO:0000269|PubMed:15169837}.
|
| Top Pathways |
Regulation of autophagy
|