ATG4B

Gene Symbol	ATG4B
Entrez Gene	23192
Alt Symbol	APG4B, AUTL1
Species	Human
Gene Type	protein-coding
Description	autophagy related 4B, cysteine peptidase
Other Description	APG4 autophagy 4 homolog B|ATG4 autophagy related 4 homolog B|AUT-like 1 cysteine endopeptidase|autophagin-1|autophagy-related cysteine endopeptidase 1|autophagy-related protein 4 homolog B|cysteine protease ATG4B|hAPG4B
Swissprots	Q6ZUV8 Q53NU4 Q96SZ1 Q96K96 Q9Y2F2 Q96K07 Q8WYM9 Q9Y4P1 B7WNK2
Accessions	AAY14919 EAW71278 EAW71279 EAW71280 EAW71281 Q9Y4P1 AB023160 BAA76787 AB066215 BAB83890 AJ504652 CAD43219 AK027332 BAB55042 AK027462 BAB55127 AK027763 BAB55353 AK123425 BAG53904 AK125277 BAC86110 AK296818 BAG59391 AK298109 BAG60394 AK302963 BAG64112 AK316167 BAH14538 AL050288 AL080168 CAB45756 AL133638 AM393751 CAL38626 BC000719 AAH00719 BX648007 CAH56198 DQ891869 ABM82795 XM_005246992 XP_005247049 XM_005246993 XP_005247050 XM_005246995 XP_005247052 XM_005246996 XP_005247053 XM_011510836 XP_011509138 XM_011510837 XP_011509139 XM_011510838 XP_011509140 XM_011510839 XP_011509141 NM_013325 NP_037457 NM_178326 NP_847896
Function	Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3, GABARAPL1, GABARAPL2 and GABARAP, to reveal a C-terminal glycine. Exposure of the glycine at the C- terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms. {ECO:0000269|PubMed:15169837, ECO:0000269|PubMed:15187094, ECO:0000269|PubMed:17347651, ECO:0000269|PubMed:19322194, ECO:0000269|PubMed:21177865, ECO:0000269|PubMed:22302004}.
Subcellular Location	Cytoplasm {ECO:0000250}.
Tissue Specificity	Mainly expressed in the skeletal muscle, followed by brain, heart, liver and pancreas. {ECO:0000269|PubMed:12446702, ECO:0000269|PubMed:15169837}.
Top Pathways	Regulation of autophagy

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human ATG4B full length protein - ab188707 from Abcam Category Protein Prices $320.00 Sizes 25 µg Source E. coli Species Human

Human ATG4B full length protein - ab123195 from Abcam Category Protein Prices $402.00 Sizes 100 µg Source E. coli Species Human

Human ATG4B peptide - ab98899 from Abcam Category Peptide Prices $176.00 Sizes 100 µg

APG4B / ATG4B Antibody Blocking Peptide - LS-E5574 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

APG4B / ATG4B Antibody Blocking Peptide - LS-E5575 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

APG4B / ATG4B Antibody Blocking Peptide - LS-E6574 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

APG4B / ATG4B Antibody Blocking Peptide - LS-E21562 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

APG4B / ATG4B Antibody Blocking Peptide - LS-E21155 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human ATG4B Protein - H00023192-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human ATG4B Protein - NBP1-99088 from Novus Biologicals Category Protein Prices $349.00, $969.00 Sizes 100 µg, 500 µg Source E. coli Species Human

APG4B-Antibody-E273-Blocking-Peptide - BP1809d from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

APG4B-Antibody-N-term-Blocking-Peptide - BP1809a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

APG4B-Antibody-Center-G254-Blocking-peptide - BP19349c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human His6-ATG4B, CF - E-400-025 from R&D Systems Category Protein Source E. coli-derived, Contains an N-terminal 6-His tag

Human ATG4B protein - orb167942 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Source E. coli

APG4B peptide - orb72334 from Biorbyt Category Peptide Prices $238.00 Sizes 500 µg

ATG4B protein (His tag) - 80R-2175 from Fitzgerald Category Protein Prices $395.00 Sizes 100 µg Source E.coli

ATG4B Blocking Peptide - abx161283 from Abbexa Category Peptide Species Human, Mouse, Monkey

APG4B / ATG4B (1-393, His-tag) - AR50256PU-N from Acris Antibodies Category Protein Prices $1,010.00 Sizes 500 µg Source E. coli Species Human

APG4B / ATG4B (1-393, His-tag) - AR50256PU-S from Acris Antibodies Category Protein Prices $410.00 Sizes 100 µg Source E. coli Species Human

APG4B / ATG4B - H00023192-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

APG4B / ATG4B - H00023192-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

ATG4B, 1-393aa, Human, His tag, E.coli - 01-P1431 from ARP American Research Products Category Protein Prices $189.00, $449.00, $1,089.00 Sizes 20 µg, 50 µg, 500 µg Species Human

ATG4B Peptide - 8073P from ProSci Category Peptide Species Human

ATG4B fusion protein - Ag7261 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

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