| Gene Symbol |
NUDT7
|
| Entrez Gene |
283927
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
nudix (nucleoside diphosphate linked moiety X)-type motif 7
|
| Other Description |
peroxisomal coenzyme A diphosphatase NUDT7
|
| Swissprots |
B4DLE5 H3BUB8 P0C024
|
| Accessions |
EAW95595 EAW95596 P0C024 AA227330 AA579048 AI927964 AK296963 BAG59507 BC172303 AAI72303 BU579534 BX387030 BX494638 CN297379 ES309123 EU981826 ACH71652 XM_011523032 XP_011521334 XM_011523033 XP_011521335 NM_001105663 NP_001099133 NM_001243657 NP_001230586 NM_001243660 NP_001230589 NM_001243661 NP_001230590
|
| Function |
Coenzyme A diphosphatase which mediates the cleavage of CoA, CoA esters and oxidized CoA with similar efficiencies, yielding 3',5'-ADP and the corresponding 4'-phosphopantetheine derivative as products. CoA into 3',5'-ADP and 4'- phosphopantetheine. Has no activity toward NDP-sugars, CDP- alcohols, (deoxy)nucleoside 5'-triphosphates, nucleoside 5'-di or monophosphates, diadenosine polyphosphates, NAD, NADH, NADP, NADPH or thymidine-5'-monophospho-p-nitrophenyl ester. May be required to eliminate oxidized CoA from peroxisomes, or regulate CoA and acyl-CoA levels in this organelle in response to metabolic demand. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Peroxisome {ECO:0000250}.
|
| Tissue Specificity |
Expressed in liver, kidney, pancreas, pituitary, small intestine, spleen, heart and placenta. Weakly expressed in brain. {ECO:0000269|PubMed:11415433}.
|
| Top Pathways |
Peroxisome
|