PNPLA2

Gene Symbol	PNPLA2
Entrez Gene	57104
Alt Symbol	1110001C14Rik, ATGL, FP17548, PEDF-R, TTS-2.2, TTS2, iPLA2zeta
Species	Human
Gene Type	protein-coding
Description	patatin-like phospholipase domain containing 2
Other Description	IPLA2-zeta|TTS2.2|adipose triglyceride lipase|calcium-independent phospholipase A2|desnutrin|patatin-like phospholipase domain containing protein 2|patatin-like phospholipase domain-containing protein 2|pigment epithelium-derived factor|transport-secretion protein 2.2|triglyceride hydrolase
Swissprots	Q9NQ62 O60643 Q96ET6 Q6XYE5 Q96AD5 Q9NQ61 Q5EFF5
Accessions	EAX02395 EAX02396 Q96AD5 AF055000 AAC09354 AJ278475 CAC01131 AJ278476 CAC01132 AK308435 AL833707 AY203925 AAP34448 AY894804 AAW81962 BC011958 AAH11958 BC017280 AAH17280 HQ651812 ADU85972 JF279441 JF279442 AEZ01596 KF601369 AIB55759 XM_006718265 XP_006718328 XM_006718266 XP_006718329 NM_020376 NP_065109
Function	Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets. Also has acylglycerol transacylase activity. May act coordinately with LIPE/HLS within the lipolytic cascade. Regulates adiposome size and may be involved in the degradation of adiposomes. May play an important role in energy homeostasis. May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion. {ECO:0000269|PubMed:15364929, ECO:0000269|PubMed:15550674, ECO:0000269|PubMed:16239926}.
Subcellular Location	Lipid droplet. Cell membrane; Single-pass type II membrane protein.
Tissue Specificity	Highest expression in adipose tissue. Also detected in heart, skeletal muscle, and portions of the gastrointestinal tract. Detected in normal retina and retinoblastoma cells. Detected in retinal pigment epithelium and, at lower intensity, in the inner segments of photoreceptors and in the ganglion cell layer of the neural retina (at protein level). {ECO:0000269|PubMed:15550674, ECO:0000269|PubMed:16150821, ECO:0000269|PubMed:16249444, ECO:0000269|PubMed:17032652}.
Top Pathways	Glycerolipid metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Rat PNPLA2 / ATGL ELISA Kit (Sandwich ELISA) - LS-F9854 from LifeSpan Bioscience Category ELISA Kit Prices $780.00 Sizes 1 plate Sensitivity 0.055 ng/ml Range 0.156-10 ng/ml

Human PNPLA2 / ATGL ELISA Kit (Sandwich ELISA) - LS-F12352 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.625 Range 0.156-10 ng/ml

Rat PNPLA2 / ATGL ELISA Kit (Sandwich ELISA) - LS-F12351 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.78 Range 0.156-10 ng/ml

Adipose Triglyceride Lipase, ATGL, Human, ELISA Kit - CSB-E12688h from ARP American Research Products Category ELISA Kit Prices $550.00, $790.00, $791.00, $794.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 1.56 mIU/ml Range 6.25 mIU/ml-400 mIU/ml

Adipose Triglyceride Lipase, Human, ELISA Kit - E01A0893 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t Sensitivity 0.1ng/ml Range 0.5-10ng/ml

Patatin-like phospholipase domain-containing protein 2, PNPLA2, Human, ELISA Kit - E8796h from ARP American Research Products Category ELISA Kit Prices $660.00 Sizes 96 t Range 0.625-40 ng/mL

Adipose Triglyceride Lipase, ATGL, Rat, ELISA Kit - E-EL-R0387 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 0.469 Range 0.781-50ng/mL

Adipose Triglyceride Lipase, ELISA Kit - MBS750961 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Adipose Triglyceride Lipase, ELISA Kit - MBS008828 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 5.0 ng/ml. Range 31.2 ng/ml - 1000 ng/ml.

Adipose Triglyceride Lipase, ELISA Kit - MBS745859 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/mL.

Adipose Triglyceride Lipase, ELISA Kit - MBS102286 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Adipose Triglyceride Lipase, ELISA Kit - MBS749970 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Adipose Triglyceride Lipase, ELISA Kit - MBS752789 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Adipose Triglyceride Lipase, ELISA Kit - MBS754582 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Adipose Triglyceride Lipase, ELISA Kit - MBS752283 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Adipose Triglyceride Lipase, ELISA Kit - MBS754335 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/mL.

Adipose Triglyceride Lipase, ELISA Kit - MBS280741 from MyBioSource Category ELISA Kit Prices $385.00, $625.00, $2,510.00, $4,790.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Adipose Triglyceride Lipase, ELISA Kit - MBS065458 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Adipose Triglyceride Lipase, ELISA Kit - MBS745660 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/mL.

Adipose Triglyceride Lipase, ELISA Kit - MBS752832 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Adipose Triglyceride Lipase, ELISA Kit - MBS087234 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Adipose Triglyceride Lipase, ELISA Kit - MBS084433 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Adipose Triglyceride Lipase, ELISA Kit - MBS746470 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Patatin Like Phospholipase Domain Containing Protein 2 (PNPLA2), ELISA Kit - MBS2022321 from MyBioSource Category ELISA Kit Prices $405.00, $605.00, $820.00, $3,375.00, $6,125.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.055ng/mL. Range 0.156-10ng/mL

Human ATGL ELISA KIT (Cell cultures or tissue) - DEIA6927 from Creative Diagnostics Category ELISA Kit Sensitivity 200 pg/mL Range 1.56-50 ng/mL

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