PNPLA2

Gene Symbol PNPLA2
Entrez Gene 57104
Alt Symbol 1110001C14Rik, ATGL, FP17548, PEDF-R, TTS-2.2, TTS2, iPLA2zeta
Species Human
Gene Type protein-coding
Description patatin-like phospholipase domain containing 2
Other Description IPLA2-zeta|TTS2.2|adipose triglyceride lipase|calcium-independent phospholipase A2|desnutrin|patatin-like phospholipase domain containing protein 2|patatin-like phospholipase domain-containing protein 2|pigment epithelium-derived factor|transport-secretion protein 2.2|triglyceride hydrolase
Swissprots Q9NQ62 O60643 Q96ET6 Q6XYE5 Q96AD5 Q9NQ61 Q5EFF5
Accessions EAX02395 EAX02396 Q96AD5 AF055000 AAC09354 AJ278475 CAC01131 AJ278476 CAC01132 AK308435 AL833707 AY203925 AAP34448 AY894804 AAW81962 BC011958 AAH11958 BC017280 AAH17280 HQ651812 ADU85972 JF279441 JF279442 AEZ01596 KF601369 AIB55759 XM_006718265 XP_006718328 XM_006718266 XP_006718329 NM_020376 NP_065109
Function Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets. Also has acylglycerol transacylase activity. May act coordinately with LIPE/HLS within the lipolytic cascade. Regulates adiposome size and may be involved in the degradation of adiposomes. May play an important role in energy homeostasis. May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion. {ECO:0000269|PubMed:15364929, ECO:0000269|PubMed:15550674, ECO:0000269|PubMed:16239926}.
Subcellular Location Lipid droplet. Cell membrane; Single-pass type II membrane protein.
Tissue Specificity Highest expression in adipose tissue. Also detected in heart, skeletal muscle, and portions of the gastrointestinal tract. Detected in normal retina and retinoblastoma cells. Detected in retinal pigment epithelium and, at lower intensity, in the inner segments of photoreceptors and in the ganglion cell layer of the neural retina (at protein level). {ECO:0000269|PubMed:15550674, ECO:0000269|PubMed:16150821, ECO:0000269|PubMed:16249444, ECO:0000269|PubMed:17032652}.
Top Pathways Glycerolipid metabolism

ATGL CRISPR/Cas9 KO Plasmid (h) - sc-401711 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ATGL HDR Plasmid (h) - sc-401711-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ATGL Double Nickase Plasmid (h) - sc-401711-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ATGL Double Nickase Plasmid (h2) - sc-401711-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ATGL CRISPR Activation Plasmid (h) - sc-401711-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ATGL CRISPR Activation Plasmid (h2) - sc-401711-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ATGL Lentiviral Activation Particles (h) - sc-401711-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ATGL Lentiviral Activation Particles (h2) - sc-401711-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ATGL siRNA (h) - sc-60223 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ATGL shRNA Plasmid (h) - sc-60223-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ATGL shRNA (h) Lentiviral Particles - sc-60223-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PEDF R/PNPLA2/ATGL RNAi - H00057104-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU035471 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN17063 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17063 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

PNPLA2 siRNA (Human) - CRJ1324 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

PNPLA2 shRNA Plasmid (Human) - CHJ1324 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

PNPLA2 miRNA 3'UTR clone - MiUTR3H-10378 from Creative biogene

Species Reactivities Human
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