PNPLA2

Gene Symbol PNPLA2
Entrez Gene 57104
Alt Symbol 1110001C14Rik, ATGL, FP17548, PEDF-R, TTS-2.2, TTS2, iPLA2zeta
Species Human
Gene Type protein-coding
Description patatin-like phospholipase domain containing 2
Other Description IPLA2-zeta|TTS2.2|adipose triglyceride lipase|calcium-independent phospholipase A2|desnutrin|patatin-like phospholipase domain containing protein 2|patatin-like phospholipase domain-containing protein 2|pigment epithelium-derived factor|transport-secretion protein 2.2|triglyceride hydrolase
Swissprots Q9NQ62 O60643 Q96ET6 Q6XYE5 Q96AD5 Q9NQ61 Q5EFF5
Accessions EAX02395 EAX02396 Q96AD5 AF055000 AAC09354 AJ278475 CAC01131 AJ278476 CAC01132 AK308435 AL833707 AY203925 AAP34448 AY894804 AAW81962 BC011958 AAH11958 BC017280 AAH17280 HQ651812 ADU85972 JF279441 JF279442 AEZ01596 KF601369 AIB55759 XM_006718265 XP_006718328 XM_006718266 XP_006718329 NM_020376 NP_065109
Function Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets. Also has acylglycerol transacylase activity. May act coordinately with LIPE/HLS within the lipolytic cascade. Regulates adiposome size and may be involved in the degradation of adiposomes. May play an important role in energy homeostasis. May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion. {ECO:0000269|PubMed:15364929, ECO:0000269|PubMed:15550674, ECO:0000269|PubMed:16239926}.
Subcellular Location Lipid droplet. Cell membrane; Single-pass type II membrane protein.
Tissue Specificity Highest expression in adipose tissue. Also detected in heart, skeletal muscle, and portions of the gastrointestinal tract. Detected in normal retina and retinoblastoma cells. Detected in retinal pigment epithelium and, at lower intensity, in the inner segments of photoreceptors and in the ganglion cell layer of the neural retina (at protein level). {ECO:0000269|PubMed:15550674, ECO:0000269|PubMed:16150821, ECO:0000269|PubMed:16249444, ECO:0000269|PubMed:17032652}.
Top Pathways Glycerolipid metabolism

ATGL Antibody - 2138 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from NIH/3T3 and differentiated NIH/3T3-L1 cells, using ATGL antibody.

ATGL (30A4) Rabbit mAb - 2439 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone 30A4
Western blot analysis of extracts from NIH/3T3 and differentiated NIH/3T3-L1 cells, using ATGL (30A4) Rabbit mAb.

ATGL (F-7) - sc-365278 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ATGL (F-7): sc-365278. Western blot analysis of ATGL expression in SJRH30 (A) and Y79 (B) whole cell lysates.

ATGL (H-144) - sc-67355 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

ATGL (P-20) - sc-50223 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ATGL (P-20): sc-50223. Western blot analysis of ATGL expression in SJRH30 whole cell lysate.

ATGL (N-12) - sc-50222 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ATGL (N-12): sc-50222. Western blot analysis of ATGL expression in Jurkat (A), K-562 (B) and Y79 (C) whole cell lysates.

ATGL (K-14) - sc-50221 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ATGL (K-14): sc-50221. Western blot analysis of ATGL expression in SJRH30 (A), Y79 (B) and HeLa (C) whole cell lysates.

Anti-Adipose Triglyceride Lipase antibody - ab99532 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC image of Adipose Triglyceride Lipase staining in Human Heart muscle formalin fixed paraffin embedded tissue section, performed on a Leica Bond™ system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab99532, 5µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.

Anti-Adipose Triglyceride Lipase antibody - ab85858 from Abcam

Prices $378.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
ab85858 at 2.5 µg/ml staining Adipose Triglyceride Lipase in formalin fixed and paraffin embedded Mouse heart tissue.

Anti-Adipose Triglyceride Lipase antibody - ab140169 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Adipose Triglyceride Lipase antibody (ab140169) at 1/500 dilutionLane 1 : Human fetal heart lysateLane 2 : Human fetal kidney lysate

Anti-Adipose Triglyceride Lipase antibody - ab154708 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Adipose Triglyceride Lipase antibody (ab154708) at 1/1000 dilution + H1299 whole cell lysate at 30 µg

Anti-Adipose Triglyceride Lipase antibody - ab77591 from Abcam

Prices $376.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-Adipose Triglyceride Lipase antibody (ab77591) at 0.2 µg/ml + human adipose lysate in RIPA buffer at 35 µg

Anti-Adipose Triglyceride Lipase antibody - ab57562 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab57562 Adipose Triglyceride Lipase antibody at 1ug/ml.

Anti-Adipose Triglyceride Lipase antibody - ab90885 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Adipose Triglyceride Lipase antibody (ab90885) at 2 µg/ml + Human adipose tissue lysate

Anti-Adipose Triglyceride Lipase antibody [AT2G2] - ab85348 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone AT2G2
Anti-Adipose Triglyceride Lipase antibody [AT2G2] (ab85348) at 1/1000 dilution + mouse kidney extract at 20 µgSecondary goat anti-mouse HRPdeveloped using the ECL technique

Anti-Adipose Triglyceride Lipase antibody [EPR3444(2)] - ab109251 from Abcam

Prices $381.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3444(2)
All lanes : Anti-Adipose Triglyceride Lipase antibody [EPR3444(2)] (ab109251) at 1/1000 dilutionLane 1 : 3T3-L1 lysateLane 2 : A431 lysateLane 3 : A673 lysateLane 4 : Human heart tissue lysateLane 5 : Human skeletal muscle tissue lysateLane 6 : Human adipose tissue lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-PNPLA2 / ATGL Antibody (C-Terminus) - LS-C46997 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PNPLA2 / ATGL Antibody (C-Terminus) - LS-C46998 from LifeSpan Bioscience

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PNPLA2 / ATGL Antibody (aa382-400) - LS-C11802 from LifeSpan Bioscience

Prices $325.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-PNPLA2 / ATGL Antibody (aa400-500) - LS-C63744 from LifeSpan Bioscience

Prices $495.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PNPLA2 / ATGL Antibody (aa30-504, clone AT2G2) - LS-C93829 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone AT2G2

Anti-PNPLA2 / ATGL Antibody (aa162-253) - LS-C124408 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µg
Host Sheep
Clonality Polyclonal

Anti-PNPLA2 / ATGL Antibody (C-Terminus, Biotin) - LS-C141425 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PNPLA2 / ATGL Antibody (C-Terminus, DY650) - LS-C141426 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PNPLA2 / ATGL Antibody (C-Terminus, DY488) - LS-C141427 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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