PNPLA2

Gene Symbol	PNPLA2
Entrez Gene	57104
Alt Symbol	1110001C14Rik, ATGL, FP17548, PEDF-R, TTS-2.2, TTS2, iPLA2zeta
Species	Human
Gene Type	protein-coding
Description	patatin-like phospholipase domain containing 2
Other Description	IPLA2-zeta|TTS2.2|adipose triglyceride lipase|calcium-independent phospholipase A2|desnutrin|patatin-like phospholipase domain containing protein 2|patatin-like phospholipase domain-containing protein 2|pigment epithelium-derived factor|transport-secretion protein 2.2|triglyceride hydrolase
Swissprots	Q9NQ62 O60643 Q96ET6 Q6XYE5 Q96AD5 Q9NQ61 Q5EFF5
Accessions	EAX02395 EAX02396 Q96AD5 AF055000 AAC09354 AJ278475 CAC01131 AJ278476 CAC01132 AK308435 AL833707 AY203925 AAP34448 AY894804 AAW81962 BC011958 AAH11958 BC017280 AAH17280 HQ651812 ADU85972 JF279441 JF279442 AEZ01596 KF601369 AIB55759 XM_006718265 XP_006718328 XM_006718266 XP_006718329 NM_020376 NP_065109
Function	Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets. Also has acylglycerol transacylase activity. May act coordinately with LIPE/HLS within the lipolytic cascade. Regulates adiposome size and may be involved in the degradation of adiposomes. May play an important role in energy homeostasis. May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion. {ECO:0000269|PubMed:15364929, ECO:0000269|PubMed:15550674, ECO:0000269|PubMed:16239926}.
Subcellular Location	Lipid droplet. Cell membrane; Single-pass type II membrane protein.
Tissue Specificity	Highest expression in adipose tissue. Also detected in heart, skeletal muscle, and portions of the gastrointestinal tract. Detected in normal retina and retinoblastoma cells. Detected in retinal pigment epithelium and, at lower intensity, in the inner segments of photoreceptors and in the ganglion cell layer of the neural retina (at protein level). {ECO:0000269|PubMed:15550674, ECO:0000269|PubMed:16150821, ECO:0000269|PubMed:16249444, ECO:0000269|PubMed:17032652}.
Top Pathways	Glycerolipid metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Adipose Triglyceride Lipase protein fragment - ab153438 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

Mouse Adipose Triglyceride Lipase (phospho S406) peptide - ab174058 from Abcam Category Peptide

Mouse Adipose Triglyceride Lipase peptide - ab174059 from Abcam Category Peptide

PNPLA2 / ATGL Antibody Blocking Peptide - LS-E21565 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PNPLA2 / ATGL Antibody Blocking Peptide - LS-E26275 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PNPLA2 / ATGL Antibody Blocking Peptide - LS-E26286 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PNPLA2 / ATGL Antibody Blocking Peptide - LS-E26651 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PEDF R/PNPLA2/ATGL Blocking Peptide - NB110-41536PEP from Novus Biologicals Category Peptide Prices $69.00 Sizes 50 µl Species Human

Recombinant Human PEDF R/PNPLA2/ATGL Protein - H00057104-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

PEDF R/PNPLA2/ATGL Blocking Peptide - NB100-57854PEP from Novus Biologicals Category Peptide Prices $229.00 Sizes 100 µg Species Human

PNPLA2-Antibody-N-term-Blocking-Peptide - BP19395a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ATGL blocking peptide - GTX89133-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Pig, Rat, Bovine

ATGL blocking peptide - GTX88800-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

ATGL blocking peptide - GTX88804-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Rat, Bovine

ATGL Blocking Peptide - 33R-10928 from Fitzgerald Category Peptide Prices $145.00 Sizes 50 µg

Adipose Triglyceride Lipase Peptide - AC21-1107-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Adipose Triglyceride Lipase Peptide - AC21-1118-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Adipose Triglyceride Lipase Peptide - AC21-1487-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

PNPLA2 / ATGL - H00057104-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

PNPLA2 / ATGL - H00057104-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

PNPLA2 / ATGL - H00057104-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PNPLA2 / ATGL - H00057104-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PNPLA2 Peptide - 46-698P from ProSci Category Peptide Species Human

PNPLA2 Peptide - 46-699P from ProSci Category Peptide Species Human

Recombinant Human PNPLA2, His-tagged - PNPLA2-322H from Creative Biomart Category Protein Source E. Coli Species Human

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