| Gene Symbol |
PHLDA1
|
| Entrez Gene |
22822
|
| Alt Symbol |
DT1P1B11, PHRIP, TDAG51
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
pleckstrin homology-like domain, family A, member 1
|
| Other Description |
PQ-rich protein|PQR protein|T-cell death-associated gene 51 protein|apoptosis-associated nuclear protein|pleckstrin homology-like domain family A member 1|proline- and glutamine-rich protein|proline- and histidine-rich protein|proline-histidine rich protein
|
| Swissprots |
Q8WV24 Q2TAN2 Q15184 A1A4G9 Q9NZ17
|
| Accessions |
AAF64165 EAW97312 EAW97313 Q8WV24 AF220656 AAF36387 AK026181 AK304224 BAG65096 BC017756 BC018929 AAH18929 BC037430 BC039558 BC047362 BC065825 BC110820 AAI10821 BC126425 AAI26426 BC130427 AAI30428 DR002699 JF432667 ADZ15884 U92983 Z50194 CAA90576 NM_007350 NP_031376
|
| Function |
Seems to be involved in regulation of apoptosis. May be involved in detachment-mediated programmed cell death. May mediate apoptosis during neuronal development. May be involved in regulation of anti-apoptotic effects of IGF1. May be involved in translational regulation. {ECO:0000269|PubMed:11369516, ECO:0000269|PubMed:12738777}.
|
| Subcellular Location |
Cytoplasm. Cytoplasmic vesicle membrane. Nucleus, nucleolus. Note=Colocalizes with intracellular vesicles.
|
| Tissue Specificity |
Widely expressed with highest levels in pancreas. Strongly expressed by benign melanocytic nevi, and progressively reduced expressed in primary and metastatic melanomas (at protein level). {ECO:0000269|PubMed:12384558, ECO:0000269|PubMed:12738777}.
|
![Western Blot: PHLDA1 Overexpression Lysate (Adult Normal) [NBL1-14367] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PHLDA1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/6680_PHLDA1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-14367-img0002.jpg)