Gene Symbol | PHLDA1 |
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Entrez Gene | 22822 |
Alt Symbol | DT1P1B11, PHRIP, TDAG51 |
Species | Human |
Gene Type | protein-coding |
Description | pleckstrin homology-like domain, family A, member 1 |
Other Description | PQ-rich protein|PQR protein|T-cell death-associated gene 51 protein|apoptosis-associated nuclear protein|pleckstrin homology-like domain family A member 1|proline- and glutamine-rich protein|proline- and histidine-rich protein|proline-histidine rich protein |
Swissprots | Q8WV24 Q2TAN2 Q15184 A1A4G9 Q9NZ17 |
Accessions | AAF64165 EAW97312 EAW97313 Q8WV24 AF220656 AAF36387 AK026181 AK304224 BAG65096 BC017756 BC018929 AAH18929 BC037430 BC039558 BC047362 BC065825 BC110820 AAI10821 BC126425 AAI26426 BC130427 AAI30428 DR002699 JF432667 ADZ15884 U92983 Z50194 CAA90576 NM_007350 NP_031376 |
Function | Seems to be involved in regulation of apoptosis. May be involved in detachment-mediated programmed cell death. May mediate apoptosis during neuronal development. May be involved in regulation of anti-apoptotic effects of IGF1. May be involved in translational regulation. {ECO:0000269|PubMed:11369516, ECO:0000269|PubMed:12738777}. |
Subcellular Location | Cytoplasm. Cytoplasmic vesicle membrane. Nucleus, nucleolus. Note=Colocalizes with intracellular vesicles. |
Tissue Specificity | Widely expressed with highest levels in pancreas. Strongly expressed by benign melanocytic nevi, and progressively reduced expressed in primary and metastatic melanomas (at protein level). {ECO:0000269|PubMed:12384558, ECO:0000269|PubMed:12738777}. |
TDAG51 CRISPR/Cas9 KO Plasmid (h) - sc-401042 from Santa Cruz Biotechnology
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TDAG51 HDR Plasmid (h) - sc-401042-HDR from Santa Cruz Biotechnology
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TDAG51 Double Nickase Plasmid (h) - sc-401042-NIC from Santa Cruz Biotechnology
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TDAG51 Double Nickase Plasmid (h2) - sc-401042-NIC-2 from Santa Cruz Biotechnology
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TDAG51 CRISPR Activation Plasmid (h) - sc-401042-ACT from Santa Cruz Biotechnology
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TDAG51 CRISPR Activation Plasmid (h2) - sc-401042-ACT-2 from Santa Cruz Biotechnology
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TDAG51 Lentiviral Activation Particles (h) - sc-401042-LAC from Santa Cruz Biotechnology
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TDAG51 Lentiviral Activation Particles (h2) - sc-401042-LAC-2 from Santa Cruz Biotechnology
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TDAG51 siRNA (h) - sc-36631 from Santa Cruz Biotechnology
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TDAG51 shRNA Plasmid (h) - sc-36631-SH from Santa Cruz Biotechnology
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TDAG51 shRNA (h) Lentiviral Particles - sc-36631-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU136861 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16743 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16743 from Sigma-Aldrich
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PHLDA1 siRNA (Human) - CRH7790 from Cohesion Biosciences
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shRNA set against Human PHLDA1 (NM_007350.3) - SHH374928 from Creative biogene
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Human PHLDA1 siRNA - orb268292 from Biorbyt
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PHLDA1 shRNA Plasmid (Human) - CHH7790 from Cohesion Biosciences
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PHLDA1 miRNA 3'UTR clone - MiUTR1H-07868 from Creative biogene
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