| Gene Symbol |
SSPN
|
| Entrez Gene |
8082
|
| Alt Symbol |
DAGA5, KRAG, NSPN, SPN1, SPN2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
sarcospan
|
| Other Description |
K-ras oncogene-associated protein|Kras oncogene-associated|kirsten-ras-associated protein|microspan|nanospan|sarcospan (Kras oncogene-associated gene)
|
| Swissprots |
Q14714 B3KS67
|
| Accessions |
EAW96532 Q14714 AF016028 AAC61660 AK092925 BAG52629 AK304667 BAG65442 AK314353 BAG36988 AL136756 CAB66690 AM392675 CAL37553 AM392714 CAL37592 BC041929 BC062299 AAH62299 BP341300 CA419006 DA073350 DQ897666 ABI78937 EU433933 ACA09756 X89105 CAA61479 XM_011520853 XP_011519155 XM_011520854 XP_011519156 XM_011520855 XP_011519157 NM_001135823 NP_001129295 NM_005086 NP_005077
|
| Function |
Component of the dystrophin-glycoprotein complex (DGC), a complex that spans the muscle plasma membrane and forms a link between the F-actin cytoskeleton and the extracellular matrix. Preferentially associates with the sarcoglycan subcomplex of the DGC.
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell membrane, sarcolemma {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Also found in myotendinous junctions and in the postsynaptic membrane of neuromuscular junctions. {ECO:0000250}.
|
| Tissue Specificity |
Isoform 1 is expressed exclusively in heart and skeletal muscle. Isoform 2 is expressed in heart, skeletal muscle, thymus, prostate, testis, ovary, small intestine, colon and spleen.
|