| Gene Symbol | SSPN |
|---|---|
| Entrez Gene | 8082 |
| Alt Symbol | DAGA5, KRAG, NSPN, SPN1, SPN2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | sarcospan |
| Other Description | K-ras oncogene-associated protein|Kras oncogene-associated|kirsten-ras-associated protein|microspan|nanospan|sarcospan (Kras oncogene-associated gene) |
| Swissprots | Q14714 B3KS67 |
| Accessions | EAW96532 Q14714 AF016028 AAC61660 AK092925 BAG52629 AK304667 BAG65442 AK314353 BAG36988 AL136756 CAB66690 AM392675 CAL37553 AM392714 CAL37592 BC041929 BC062299 AAH62299 BP341300 CA419006 DA073350 DQ897666 ABI78937 EU433933 ACA09756 X89105 CAA61479 XM_011520853 XP_011519155 XM_011520854 XP_011519156 XM_011520855 XP_011519157 NM_001135823 NP_001129295 NM_005086 NP_005077 |
| Function | Component of the dystrophin-glycoprotein complex (DGC), a complex that spans the muscle plasma membrane and forms a link between the F-actin cytoskeleton and the extracellular matrix. Preferentially associates with the sarcoglycan subcomplex of the DGC. |
| Subcellular Location | Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell membrane, sarcolemma {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Also found in myotendinous junctions and in the postsynaptic membrane of neuromuscular junctions. {ECO:0000250}. |
| Tissue Specificity | Isoform 1 is expressed exclusively in heart and skeletal muscle. Isoform 2 is expressed in heart, skeletal muscle, thymus, prostate, testis, ovary, small intestine, colon and spleen. |
Sarcospan CRISPR/Cas9 KO Plasmid (h) - sc-403661 from Santa Cruz Biotechnology
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Sarcospan HDR Plasmid (h) - sc-403661-HDR from Santa Cruz Biotechnology
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Sarcospan Double Nickase Plasmid (h) - sc-403661-NIC from Santa Cruz Biotechnology
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Sarcospan Double Nickase Plasmid (h2) - sc-403661-NIC-2 from Santa Cruz Biotechnology
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Sarcospan CRISPR Activation Plasmid (h) - sc-403661-ACT from Santa Cruz Biotechnology
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Sarcospan CRISPR Activation Plasmid (h2) - sc-403661-ACT-2 from Santa Cruz Biotechnology
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Sarcospan Lentiviral Activation Particles (h) - sc-403661-LAC from Santa Cruz Biotechnology
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Sarcospan Lentiviral Activation Particles (h2) - sc-403661-LAC-2 from Santa Cruz Biotechnology
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Sarcospan siRNA (h) - sc-43426 from Santa Cruz Biotechnology
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Sarcospan shRNA Plasmid (h) - sc-43426-SH from Santa Cruz Biotechnology
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Sarcospan shRNA (h) Lentiviral Particles - sc-43426-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU130621 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN20625 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20625 from Sigma-Aldrich
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SSPN siRNA (Human) - CRH5361 from Cohesion Biosciences
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SSPN - MBS8209561 from MyBioSource
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shRNA set against Human SSPN (NM_005086.4) - SHH418460 from Creative biogene
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Human SSPN siRNA - orb265863 from Biorbyt
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SSPN shRNA Plasmid (Human) - CHH5361 from Cohesion Biosciences
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SSPN miRNA 3'UTR clone - MiUTR4H-TG08559 from Creative biogene
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