TRPV1

Gene Symbol TRPV1
Entrez Gene 7442
Alt Symbol VR1
Species Human
Gene Type protein-coding
Description transient receptor potential cation channel, subfamily V, member 1
Other Description OTRPC1|capsaicin receptor|osm-9-like TRP channel 1|transient receptor potential cation channel subfamily V member 1|transient receptor potential vanilloid 1a|transient receptor potential vanilloid 1b|vanilloid receptor subtype 1
Swissprots Q9H304 A2RUA9 Q8NER1 Q9NY22 Q3LU47 Q9H0G9 Q9NQ74 Q9H303
Accessions EAW90497 EAW90498 EAW90499 EAW90500 Q8NER1 AA700014 AF196175 AAG43466 AF196176 AAG43467 AF235160 AAN73432 AJ272063 CAB89866 AJ277028 CAB95729 AL136801 CAB66735 AM393687 CAL38563 AY131289 AAM89472 AY986821 AAX84657 BC132820 AAI32821 BC136633 AAI36634 BF308801 DQ177332 ABA06605 DQ177333 ABA06606 DQ898279 ABI58280 NM_018727 NP_061197 NM_080704 NP_542435 NM_080705 NP_542436 NM_080706 NP_542437
Function Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Can be activated by endogenous compounds, including 12- hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis (By similarity). Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits a time- and Ca(2+)-dependent outward rectification, followed by a long-lasting refractory state. Mil
Subcellular Location Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell projection, dendritic spine membrane {ECO:0000250}; Multi- pass membrane protein {ECO:0000250}. Cell membrane {ECO:0000269|PubMed:12077606}; Multi-pass membrane protein {ECO:0000269|PubMed:12077606}. Note=Mostly, but not exclusively expressed in postsynaptic dendritic spines. {ECO:0000250}.
Tissue Specificity Widely expressed at low levels. Expression is elevated in dorsal root ganglia. In skin, expressed in cutaneous sensory nerve fibers, mast cells, epidermal keratinocytes, dermal blood vessels, the inner root sheet and the infundibulum of hair follicles, differentiated sebocytes, sweat gland ducts, and the secretory portion of eccrine sweat glands (at protein level). {ECO:0000269|PubMed:11050376, ECO:0000269|PubMed:11243859, ECO:0000269|PubMed:14987252}.
Top Pathways Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction

Mouse VR1 / TRPV1 ELISA Kit (Sandwich ELISA) - LS-F7453 from LifeSpan Bioscience

Category ELISA Kit
Prices $740.00
Sizes 1 plate
Sensitivity 0.055 ng/ml
Range 0.156-10 ng/ml

Human VR1 / TRPV1 ELISA Kit (Sandwich ELISA) - LS-F7693 from LifeSpan Bioscience

Category ELISA Kit
Prices $720.00
Sizes 1 plate
Sensitivity 0.114 ng/ml
Range 0.156-10 ng/ml

Human VR1 / TRPV1 ELISA Kit (Sandwich ELISA) - LS-F12857 from LifeSpan Bioscience

Category ELISA Kit
Prices $600.00
Sizes 1 plate
Sensitivity 0.156
Range 0.156-10 ng/ml

Transient receptor potential cation channel subfamily V member 1, TRPV1, Human, ELISA Kit - E12152h from ARP American Research Products

Category ELISA Kit
Prices $596.00
Sizes 96 t
Range 0.156-10 ng/mL

Transient receptor potential cation channel, subfamily V, member 1, Human, ELISA Kit - E01T0506 from ARP American Research Products

Category ELISA Kit
Prices $535.00, $735.00
Sizes 48 t, 96 t

Transient Receptor Potential Cation Channel Subfamily V, Member 1 (TRPV1), ELISA Kit - MBS2019906 from MyBioSource

Category ELISA Kit
Prices $380.00, $565.00, $765.00, $3,130.00, $5,670.00
Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity <0.121ng/mL
Range 0.312-20ng/mL

Transient Receptor Potential Cation Channel Subfamily V, Member 1 (TRPV1), ELISA Kit - MBS2021619 from MyBioSource

Category ELISA Kit
Prices $385.00, $575.00, $785.00, $3,210.00, $5,825.00
Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity Typically less than 0.055ng/mL.
Range 0.156-10ng/mL

Transient receptor potential cation channel, subfamily V, member 1, ELISA Kit - MBS749341 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Transient receptor potential cation channel, subfamily V, member 1, ELISA Kit - MBS749600 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Transient receptor potential cation channel, subfamily V, member 1, ELISA Kit - MBS755242 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.1 ng/mL.

Transient receptor potential cation channel, subfamily V, member 1, ELISA Kit - MBS746033 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Transient receptor potential cation channel, subfamily V, member 1, ELISA Kit - MBS747586 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Transient receptor potential cation channel, subfamily V, member 1, ELISA Kit - MBS748108 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.1 ng/mL.

Transient receptor potential cation channel, subfamily V, member 1, ELISA Kit - MBS748633 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Transient receptor potential cation channel, subfamily V, member 1, ELISA Kit - MBS748147 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Transient receptor potential cation channel, subfamily V, member 1, ELISA Kit - MBS750239 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.1 ng/mL.

Transient receptor potential cation channel, subfamily V, member 1, ELISA Kit - MBS754164 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Transient receptor potential cation channel, subfamily V, member 1, ELISA Kit - MBS752123 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.1 ng/mL.

transient receptor potential cation channel, subfamily V, member 1, ELISA Kit - MBS704253 from MyBioSource

Category ELISA Kit
Prices $250.00, $550.00, $795.00, $2,890.00, $5,465.00
Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity The minimum detectable dose of human TrpV1 is typically less than 0.078 ng/ml.The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations.
Range 0.312 ng/ml -20 ng/ml.

ELISA Kit for Transient Receptor Potential Cation Channel Subfamily V, Member 1 (TRPV1) - SEF839Hu from Uscn Life Science Inc.

Category ELISA Kit
Sensitivity The minimum detectable dose of this kit is typically less than 0.127ng/mL.
Range 0.313-20ng/mL The standard curve concentrations used for the ELISA’s were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

ELISA Kit for Transient Receptor Potential Cation Channel Subfamily V, Member 1 (TRPV1) - SEF839Mu from Uscn Life Science Inc.

Category ELISA Kit
Sensitivity The minimum detectable dose of this kit is typically less than 0.055ng/mL.
Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human transient receptor potential cation channel subfamily V member 1 (TrpV1)ELISA Kit - CSB-E14198h from Cusabio

Category ELISA Kit
Sensitivity 0.078 ng/ml
Range 0.312 ng/ml-20 ng/ml

Dog VR1 / TRPV1 ELISA Kit (Custom ELISA) - LS-F16463 from LifeSpan Bioscience

Category ELISA Kit
Prices $700.00
Sizes 1 plate
Sensitivity To be determined
Range 0.156-10 ng/ml

Rabbit VR1 / TRPV1 ELISA Kit - LS-F16462 from LifeSpan Bioscience

Category ELISA Kit
Prices $700.00
Sizes 1 plate
Sensitivity To be determined
Range To be determined

Mouse VR1 / TRPV1 ELISA Kit (Custom ELISA) - LS-F16464 from LifeSpan Bioscience

Category ELISA Kit
Prices $600.00
Sizes 1 plate
Sensitivity To be determined
Range 0.156-10 ng/ml
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