TRPV1

Gene Symbol	TRPV1
Entrez Gene	7442
Alt Symbol	VR1
Species	Human
Gene Type	protein-coding
Description	transient receptor potential cation channel, subfamily V, member 1
Other Description	OTRPC1|capsaicin receptor|osm-9-like TRP channel 1|transient receptor potential cation channel subfamily V member 1|transient receptor potential vanilloid 1a|transient receptor potential vanilloid 1b|vanilloid receptor subtype 1
Swissprots	Q9H304 A2RUA9 Q8NER1 Q9NY22 Q3LU47 Q9H0G9 Q9NQ74 Q9H303
Accessions	EAW90497 EAW90498 EAW90499 EAW90500 Q8NER1 AA700014 AF196175 AAG43466 AF196176 AAG43467 AF235160 AAN73432 AJ272063 CAB89866 AJ277028 CAB95729 AL136801 CAB66735 AM393687 CAL38563 AY131289 AAM89472 AY986821 AAX84657 BC132820 AAI32821 BC136633 AAI36634 BF308801 DQ177332 ABA06605 DQ177333 ABA06606 DQ898279 ABI58280 NM_018727 NP_061197 NM_080704 NP_542435 NM_080705 NP_542436 NM_080706 NP_542437
Function	Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Can be activated by endogenous compounds, including 12- hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis (By similarity). Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits a time- and Ca(2+)-dependent outward rectification, followed by a long-lasting refractory state. Mil
Subcellular Location	Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell projection, dendritic spine membrane {ECO:0000250}; Multi- pass membrane protein {ECO:0000250}. Cell membrane {ECO:0000269|PubMed:12077606}; Multi-pass membrane protein {ECO:0000269|PubMed:12077606}. Note=Mostly, but not exclusively expressed in postsynaptic dendritic spines. {ECO:0000250}.
Tissue Specificity	Widely expressed at low levels. Expression is elevated in dorsal root ganglia. In skin, expressed in cutaneous sensory nerve fibers, mast cells, epidermal keratinocytes, dermal blood vessels, the inner root sheet and the infundibulum of hair follicles, differentiated sebocytes, sweat gland ducts, and the secretory portion of eccrine sweat glands (at protein level). {ECO:0000269|PubMed:11050376, ECO:0000269|PubMed:11243859, ECO:0000269|PubMed:14987252}.
Top Pathways	Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

TRPV1 overexpression lysate - LY403317 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

TRPV1 overexpression lysate - LY409038 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

TRPV1 overexpression lysate - LY409039 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

TRPV1 overexpression lysate - LY412871 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

TRPV1 overexpression lysate - LY429585 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

TRPV1 overexpression lysate - LY429951 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

TRPV1 overexpression lysate - LY429952 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

TRPV1 293 Cell Lysate - 406273 from ABBIOTEC Category Cell Lysate Prices $672.00 Sizes 100 µg

TRPV1 293 Cell Lysate - 402878 from ABBIOTEC Category Cell Lysate Prices $672.00 Sizes 100 µg

Vanilloid R1/TRPV1 Overexpression Lysate (Native) - NBL1-17340 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

Vanilloid R1/TRPV1 Overexpression Lysate (Native) - NBP2-05759 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

Vanilloid R1/TRPV1 Overexpression Lysate (Native) - NBP2-05758 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

Vanilloid R1/TRPV1 Overexpression Lysate (Native) - NBP2-06759 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

VR1 (h): 293T Lysate - sc-158096 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

TRPV1 Over-expression Lysate Product - GWB-B831B0 from Genway Biotech Category Cell Lysate Prices $756.00 Sizes 100 µg

TRPV1 Over-expression Lysate Product - GWB-1B7A3F from Genway Biotech Category Cell Lysate Prices $756.00 Sizes 100 µg Species Human

Vanilloid R1/TRPV1 Overexpression Lysate (Native) - NBP2-09959 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

Vanilloid R1/TRPV1 Overexpression Lysate (Native) - NBP2-09958 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

Vanilloid R1/TRPV1 Overexpression Lysate (Native) - NBP2-09889 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

Panoply™ Human TRPV1 Knockdown Stable Cell Line - CSC-DC016689 from Creative biogene Category Cell Line Species Human

TRPV1 KO Cell Lysate-HEK293T - CLKO-0977 from Creative biogene Category Cell Lysate

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