TRPV1
| Gene Symbol | TRPV1 |
|---|---|
| Entrez Gene | 7442 |
| Alt Symbol | VR1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | transient receptor potential cation channel, subfamily V, member 1 |
| Other Description | OTRPC1|capsaicin receptor|osm-9-like TRP channel 1|transient receptor potential cation channel subfamily V member 1|transient receptor potential vanilloid 1a|transient receptor potential vanilloid 1b|vanilloid receptor subtype 1 |
| Swissprots | Q9H304 A2RUA9 Q8NER1 Q9NY22 Q3LU47 Q9H0G9 Q9NQ74 Q9H303 |
| Accessions | EAW90497 EAW90498 EAW90499 EAW90500 Q8NER1 AA700014 AF196175 AAG43466 AF196176 AAG43467 AF235160 AAN73432 AJ272063 CAB89866 AJ277028 CAB95729 AL136801 CAB66735 AM393687 CAL38563 AY131289 AAM89472 AY986821 AAX84657 BC132820 AAI32821 BC136633 AAI36634 BF308801 DQ177332 ABA06605 DQ177333 ABA06606 DQ898279 ABI58280 NM_018727 NP_061197 NM_080704 NP_542435 NM_080705 NP_542436 NM_080706 NP_542437 |
| Function | Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Can be activated by endogenous compounds, including 12- hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis (By similarity). Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits a time- and Ca(2+)-dependent outward rectification, followed by a long-lasting refractory state. Mil |
| Subcellular Location | Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell projection, dendritic spine membrane {ECO:0000250}; Multi- pass membrane protein {ECO:0000250}. Cell membrane {ECO:0000269|PubMed:12077606}; Multi-pass membrane protein {ECO:0000269|PubMed:12077606}. Note=Mostly, but not exclusively expressed in postsynaptic dendritic spines. {ECO:0000250}. |
| Tissue Specificity | Widely expressed at low levels. Expression is elevated in dorsal root ganglia. In skin, expressed in cutaneous sensory nerve fibers, mast cells, epidermal keratinocytes, dermal blood vessels, the inner root sheet and the infundibulum of hair follicles, differentiated sebocytes, sweat gland ducts, and the secretory portion of eccrine sweat glands (at protein level). {ECO:0000269|PubMed:11050376, ECO:0000269|PubMed:11243859, ECO:0000269|PubMed:14987252}. |
| Top Pathways | Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction |
VR1 CRISPR/Cas9 KO Plasmid (h) - sc-400278 from Santa Cruz Biotechnology
|
||||||||
VR1 HDR Plasmid (h) - sc-400278-HDR from Santa Cruz Biotechnology
|
||||||||
VR1 Double Nickase Plasmid (h) - sc-400278-NIC from Santa Cruz Biotechnology
|
||||||||
VR1 Double Nickase Plasmid (h2) - sc-400278-NIC-2 from Santa Cruz Biotechnology
|
||||||||
VR1 CRISPR Activation Plasmid (h) - sc-400278-ACT from Santa Cruz Biotechnology
|
||||||||
VR1 CRISPR Activation Plasmid (h2) - sc-400278-ACT-2 from Santa Cruz Biotechnology
|
||||||||
VR1 Lentiviral Activation Particles (h) - sc-400278-LAC from Santa Cruz Biotechnology
|
||||||||
VR1 Lentiviral Activation Particles (h2) - sc-400278-LAC-2 from Santa Cruz Biotechnology
|
||||||||
VR1 siRNA (h) - sc-36826 from Santa Cruz Biotechnology
|
||||||||
VR1 shRNA Plasmid (h) - sc-36826-SH from Santa Cruz Biotechnology
|
||||||||
VR1 shRNA (h) Lentiviral Particles - sc-36826-V from Santa Cruz Biotechnology
|
||||||||
Vanilloid R1/TRPV1 RNAi - H00007442-R01 from Novus Biologicals
|
||||||||
Vanilloid R1/TRPV1 RNAi - H00007442-R03 from Novus Biologicals
|
||||||||
Vanilloid R1/TRPV1 RNAi - H00007442-R02 from Novus Biologicals
|
||||||||
MISSION® esiRNA - EHU073721 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN22063 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22063 from Sigma-Aldrich
|
||||||||
TRPV1 siRNA (Human) - CRH5092 from Cohesion Biosciences
|
||||||||
Vanilloid R1/TRPV1 RNAi - H00007442-R04 from Novus Biologicals
|
||||||||
TRPV1 - MBS8211481 from MyBioSource
|
||||||||
shRNA set against Human TRPV1 (NM_018727.5) - SHH435744 from Creative biogene
|
||||||||
shRNA set against Human TRPV1(NM_018727.5) - SHL097704 from Creative biogene
|
||||||||
Human TRPV1 siRNA - orb265594 from Biorbyt
|
||||||||
TRPV1 shRNA Plasmid (Human) - CHH5092 from Cohesion Biosciences
|
||||||||
TRPV1 miRNA 3'UTR clone - MiUTR1H-10794 from Creative biogene
|