CBLC

Gene Symbol CBLC
Entrez Gene 23624
Alt Symbol CBL-3, CBL-SL, RNF57
Species Human
Gene Type protein-coding
Description Cbl proto-oncogene C, E3 ubiquitin protein ligase
Other Description Cas-Br-M (murine) ecotropic retroviral transforming sequence c|Cas-Br-M (murine) ectropic retroviral transforming sequence c|Cbl proto-oncogene, E3 ubiquitin protein ligase C|E3 ubiquitin-protein ligase CBL-C|RING finger protein 57|SH3-binding protein CBL-3|SH3-binding protein CBL-C|signal transduction protein CBL-C
Swissprots Q8N1E5 Q9ULV8 Q9Y5Z3 Q9Y5Z2
Accessions EAW57292 EAW57293 Q9ULV8 AB028645 BAA86298 AF117646 AAD34341 AF117647 AAD34342 BC028915 AAH28915 BF835530 DQ891243 ABM82169 DQ894493 ABM85419 XM_005258696 XP_005258753 XM_011526688 XP_011524990 XM_011526689 XP_011524991 XM_011526690 XP_011524992 XR_243917 XR_935783 NM_001130852 NP_001124324 NM_012116 NP_036248
Function Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction; upon EGF activation, ubiquitinates EGFR. Isoform 1, but not isoform 2, inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at 'Tyr-419'. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation; CD2AP converts it from an inhibitor to a promoter of RET degradation; the function limits the potency of GDNF on neuronal survival. {ECO:0000269|PubMed:10362357, ECO:0000269|PubMed:14661060, ECO:0000269|PubMed:18753381, ECO:0000269|PubMed:20525694, ECO:0000269|PubMed:23145173}.
Tissue Specificity Ubiquitous. {ECO:0000269|PubMed:10362357}.
Top Pathways Proteoglycans in cancer, Ubiquitin mediated proteolysis, Bacterial invasion of epithelial cells, Endocytosis, ErbB signaling pathway

Cbl-3 (F-2) - sc-390648 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Cbl-3 (F-2): sc-390648. Western blot analysis of Cbl-3 expression in non-transfected: sc-117752 (A) and human Cbl-3 transfected: sc-176341 (B) 293T whole cell lysates.

Cbl-3 (G-6) - sc-390649 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Cbl-3 (G-6): sc-390649. Western blot analysis of Cbl-3 expression in non-transfected: sc-117752 (A) and human Cbl-3 transfected: sc-176341 (B) 293T whole cell lysates.

Cbl-3 (C-17) - sc-8372 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Cbl-3 (C-17): sc-8372. Western blot analysis of Cbl-3 expression in non-transfected: sc-117752 (A) and human Cbl-3 transfected: sc-176341 (B) 293T whole cell lysates.

Cbl-3 (N-19) - sc-8371 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Cbl-3 (N-19): sc-8371. Immunoperoxidase staining of formalin fixed, paraffin-embedded human small intestine tissue showing cytoplasmic staining of glandular cells.

Cbl-3 (H-128) - sc-292815 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-Cbl-c antibody - ab34750 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Cbl-c antibody (ab34750) at 1/500 dilutionLane 1 : Hek 293T cell lysate transfected with empty vectorLane 2 : Hek 293T cell lysate transfected with Cbl-c.Lane 3 : Hek 293T cell lysate transfected with empty vectorLane 4 : Hek 293T cell lysate transfected with Cbl-c.

Anti-Cbl-c antibody [3D9] - ab139329 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3D9
All lanes : Anti-Cbl-c antibody [3D9] (ab139329) at 1/2000 dilutionLane 1 : lysate from HEK293T cells transfected with the pCMV6-ENTRY control vector for 48 hrsLane 2 : lysate from HEK293T cells transfected with the pCMV6-ENTRY Cbl-c vector for 48 hrsLysates/proteins at 5 µg per lane.

Anti-Cbl-c antibody - C-terminal - ab200094 from Abcam

Host Rabbit
Clonality Polyclonal
All lanes : Anti-Cbl-c antibody - C-terminal (ab200094) at 1/1000 dilutionLane 1 : Mouse brain total cell extractLane 2 : Mouse thymus total cell extractLane 3 : HeLa total cell extractLane 4 : Jurkat total cell extract

Anti-CBLC Antibody (clone 3D9) - LS-C174117 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3D9
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY CBLC (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-CBLC.

Anti-CBLC Antibody (N-Terminus, PE) - LS-C275744 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CBLC Antibody - LS-C306754 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-CBLC Antibody - LS-C309731 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CBLC Antibody (aa73-395) - LS-C311714 from LifeSpan Bioscience

Prices $250.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-CBLC Antibody (aa253-448) - LS-C311855 from LifeSpan Bioscience

Prices $250.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-CBLC Antibody (N-Terminus) - LS-C326979 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CBLC Antibody (N-Terminus) - LS-C326980 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CBLC Antibody (aa1-30) - LS-C98809 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.

Anti-CBLC Antibody (aa424-453) - LS-C98810 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.

Anti-CBLC Antibody (clone 3B4) - LS-C174127 from LifeSpan Bioscience

Prices $350.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3B4
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY CBLC (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-CBLC.

Anti-CBLC Antibody (aa244-474, clone 4E3) - LS-C337820 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 4E3
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY CBLC (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-CBLC.

Anti-CBLC Antibody (aa444-458) IHC-plus™ - LS-B208 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-CBLC antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B208 concentration 5 ug/ml.

Anti-CBLC Antibody (C-Terminus, AP) - LS-C275728 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CBLC Antibody (C-Terminus, APC) - LS-C275729 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CBLC Antibody (C-Terminus, Biotin) - LS-C275731 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CBLC Antibody (C-Terminus, FITC) - LS-C275734 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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