CBLC

Gene Symbol CBLC
Entrez Gene 23624
Alt Symbol CBL-3, CBL-SL, RNF57
Species Human
Gene Type protein-coding
Description Cbl proto-oncogene C, E3 ubiquitin protein ligase
Other Description Cas-Br-M (murine) ecotropic retroviral transforming sequence c|Cas-Br-M (murine) ectropic retroviral transforming sequence c|Cbl proto-oncogene, E3 ubiquitin protein ligase C|E3 ubiquitin-protein ligase CBL-C|RING finger protein 57|SH3-binding protein CBL-3|SH3-binding protein CBL-C|signal transduction protein CBL-C
Swissprots Q8N1E5 Q9ULV8 Q9Y5Z3 Q9Y5Z2
Accessions EAW57292 EAW57293 Q9ULV8 AB028645 BAA86298 AF117646 AAD34341 AF117647 AAD34342 BC028915 AAH28915 BF835530 DQ891243 ABM82169 DQ894493 ABM85419 XM_005258696 XP_005258753 XM_011526688 XP_011524990 XM_011526689 XP_011524991 XM_011526690 XP_011524992 XR_243917 XR_935783 NM_001130852 NP_001124324 NM_012116 NP_036248
Function Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction; upon EGF activation, ubiquitinates EGFR. Isoform 1, but not isoform 2, inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at 'Tyr-419'. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation; CD2AP converts it from an inhibitor to a promoter of RET degradation; the function limits the potency of GDNF on neuronal survival. {ECO:0000269|PubMed:10362357, ECO:0000269|PubMed:14661060, ECO:0000269|PubMed:18753381, ECO:0000269|PubMed:20525694, ECO:0000269|PubMed:23145173}.
Tissue Specificity Ubiquitous. {ECO:0000269|PubMed:10362357}.
Top Pathways Proteoglycans in cancer, Ubiquitin mediated proteolysis, Bacterial invasion of epithelial cells, Endocytosis, ErbB signaling pathway

CBLC-Antibody-C-term-Blocking-peptide - BP1258a from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

CBLC-Antibody-N-term-Blocking-peptide - BP1257a from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

Human CBLC protein (GST Tag) - orb138318 from Biorbyt

Category Protein
Prices $323.00, $646.00
Sizes 20 μg, 100 μg
Source Baculovirus-Insect Cells
Species Human
SDS-PAGE analysis of human CBLC protein (GST Tag)

CBLC / RNF57 - H00023624-P01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Species Human

CBLC / RNF57 - H00023624-P01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Species Human

CBLC fusion protein - Ag16787 from Proteintech Group

Category Protein
Prices $199.00
Sizes 50 μg
Source E. coli -derived, PET28a
Species Human

CBLC fusion protein - Ag3747 from Proteintech Group

Category Protein
Prices $199.00
Sizes 50 μg
Source E. coli -derived, PGEX-4T
Species Human

Recombinant Human CBLC, His-tagged - CBLC-10757H from Creative Biomart

Category Protein
Source E.coli
Species Human

Recombinant Human CBLC, His-GST tagged - CBLC-442H from Creative Biomart

Category Protein
Source Baculovirus-Insect cells
Species Human

Recombinant Human Signal transduction protein CBL-C(CBLC) - CSB-YP892346HU CSB-EP892346HU CSB-BP892346HU CSB-MP892346HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

CBLC Protein - abx164550 from Abbexa

Category Protein
Species Human

CBLC / RNF57 (transcript variant 1) - TP305130 from Acris Antibodies

Category Protein
Prices $680.00
Sizes 20 µg
Source HEK293 cells
Species Human
CBLC / RNF57

Cbl-c / CBL-3, Recombinant Protein - MBS2545223 from MyBioSource

Category Protein
Prices $375.00, $905.00
Sizes 20 µg, 100 µg
Source Baculovirus-Insect Cells

Signal transduction protein CBL-C (CBLC), Recombinant Protein - MBS1453296 from MyBioSource

Category Protein
Prices $1,260.00, $1,260.00, $1,475.00, $1,475.00, $2,050.00, $2,050.00, $2,515.00, $2,515.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human
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