| Gene Symbol |
CBLC
|
| Entrez Gene |
23624
|
| Alt Symbol |
CBL-3, CBL-SL, RNF57
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Cbl proto-oncogene C, E3 ubiquitin protein ligase
|
| Other Description |
Cas-Br-M (murine) ecotropic retroviral transforming sequence c|Cas-Br-M (murine) ectropic retroviral transforming sequence c|Cbl proto-oncogene, E3 ubiquitin protein ligase C|E3 ubiquitin-protein ligase CBL-C|RING finger protein 57|SH3-binding protein CBL-3|SH3-binding protein CBL-C|signal transduction protein CBL-C
|
| Swissprots |
Q8N1E5 Q9ULV8 Q9Y5Z3 Q9Y5Z2
|
| Accessions |
EAW57292 EAW57293 Q9ULV8 AB028645 BAA86298 AF117646 AAD34341 AF117647 AAD34342 BC028915 AAH28915 BF835530 DQ891243 ABM82169 DQ894493 ABM85419 XM_005258696 XP_005258753 XM_011526688 XP_011524990 XM_011526689 XP_011524991 XM_011526690 XP_011524992 XR_243917 XR_935783 NM_001130852 NP_001124324 NM_012116 NP_036248
|
| Function |
Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction; upon EGF activation, ubiquitinates EGFR. Isoform 1, but not isoform 2, inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at 'Tyr-419'. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation; CD2AP converts it from an inhibitor to a promoter of RET degradation; the function limits the potency of GDNF on neuronal survival. {ECO:0000269|PubMed:10362357, ECO:0000269|PubMed:14661060, ECO:0000269|PubMed:18753381, ECO:0000269|PubMed:20525694, ECO:0000269|PubMed:23145173}.
|
| Tissue Specificity |
Ubiquitous. {ECO:0000269|PubMed:10362357}.
|
| Top Pathways |
Proteoglycans in cancer, Ubiquitin mediated proteolysis, Bacterial invasion of epithelial cells, Endocytosis, ErbB signaling pathway
|