| Gene Symbol | CBLC |
|---|---|
| Entrez Gene | 23624 |
| Alt Symbol | CBL-3, CBL-SL, RNF57 |
| Species | Human |
| Gene Type | protein-coding |
| Description | Cbl proto-oncogene C, E3 ubiquitin protein ligase |
| Other Description | Cas-Br-M (murine) ecotropic retroviral transforming sequence c|Cas-Br-M (murine) ectropic retroviral transforming sequence c|Cbl proto-oncogene, E3 ubiquitin protein ligase C|E3 ubiquitin-protein ligase CBL-C|RING finger protein 57|SH3-binding protein CBL-3|SH3-binding protein CBL-C|signal transduction protein CBL-C |
| Swissprots | Q8N1E5 Q9ULV8 Q9Y5Z3 Q9Y5Z2 |
| Accessions | EAW57292 EAW57293 Q9ULV8 AB028645 BAA86298 AF117646 AAD34341 AF117647 AAD34342 BC028915 AAH28915 BF835530 DQ891243 ABM82169 DQ894493 ABM85419 XM_005258696 XP_005258753 XM_011526688 XP_011524990 XM_011526689 XP_011524991 XM_011526690 XP_011524992 XR_243917 XR_935783 NM_001130852 NP_001124324 NM_012116 NP_036248 |
| Function | Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction; upon EGF activation, ubiquitinates EGFR. Isoform 1, but not isoform 2, inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at 'Tyr-419'. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation; CD2AP converts it from an inhibitor to a promoter of RET degradation; the function limits the potency of GDNF on neuronal survival. {ECO:0000269|PubMed:10362357, ECO:0000269|PubMed:14661060, ECO:0000269|PubMed:18753381, ECO:0000269|PubMed:20525694, ECO:0000269|PubMed:23145173}. |
| Tissue Specificity | Ubiquitous. {ECO:0000269|PubMed:10362357}. |
| Top Pathways | Proteoglycans in cancer, Ubiquitin mediated proteolysis, Bacterial invasion of epithelial cells, Endocytosis, ErbB signaling pathway |
Cbl-3 CRISPR/Cas9 KO Plasmid (h) - sc-407624 from Santa Cruz Biotechnology
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Cbl-3 HDR Plasmid (h) - sc-407624-HDR from Santa Cruz Biotechnology
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Cbl-3 Double Nickase Plasmid (h) - sc-407624-NIC from Santa Cruz Biotechnology
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Cbl-3 Double Nickase Plasmid (h2) - sc-407624-NIC-2 from Santa Cruz Biotechnology
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Cbl-3 CRISPR Activation Plasmid (h) - sc-407624-ACT from Santa Cruz Biotechnology
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Cbl-3 CRISPR Activation Plasmid (h2) - sc-407624-ACT-2 from Santa Cruz Biotechnology
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Cbl-3 Lentiviral Activation Particles (h) - sc-407624-LAC from Santa Cruz Biotechnology
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Cbl-3 Lentiviral Activation Particles (h2) - sc-407624-LAC-2 from Santa Cruz Biotechnology
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Cbl-3 siRNA (h) - sc-40390 from Santa Cruz Biotechnology
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Cbl-3 shRNA Plasmid (h) - sc-40390-SH from Santa Cruz Biotechnology
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Cbl-3 shRNA (h) Lentiviral Particles - sc-40390-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU070701 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5410 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5410 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR00753 from Sigma-Aldrich
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CBLC siRNA (Human) - CRH8404 from Cohesion Biosciences
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CBLC - MBS8224277 from MyBioSource
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shRNA set against Human CBLC (NM_012116.3) - SHH255321 from Creative biogene
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Human CBLC siRNA - orb268906 from Biorbyt
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CBLC shRNA Plasmid (Human) - CHH8404 from Cohesion Biosciences
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CBLC miRNA 3'UTR clone - MiUTR3H-10014 from Creative biogene
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CBLC miRNA 3'UTR clone - MiUTR3H-10015 from Creative biogene
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